• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Hedgehog pathway mutations in T-cell acute lymphoblastic leukemia.

作者信息

Dagklis Antonis, Pauwels Daphnie, Lahortiga Idoya, Geerdens Ellen, Bittoun Emilie, Cauwelier Barbara, Tousseyn Thomas, Uyttebroeck Anne, Maertens Johan, Verhoef Gregor, Vandenberghe Peter, Cools Jan

机构信息

Center for the Biology of the Disease, VIB, Leuven Center for Human Genetics, KU Leuven.

Department of Pathology UZ Leuven.

出版信息

Haematologica. 2015 Mar;100(3):e102-5. doi: 10.3324/haematol.2014.119248. Epub 2014 Dec 19.

DOI:10.3324/haematol.2014.119248
PMID:25527561
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4349289/
Abstract
摘要

相似文献

1
Hedgehog pathway mutations in T-cell acute lymphoblastic leukemia.T细胞急性淋巴细胞白血病中的刺猬信号通路突变
Haematologica. 2015 Mar;100(3):e102-5. doi: 10.3324/haematol.2014.119248. Epub 2014 Dec 19.
2
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.Gli1与DNA的相互作用是 Hedgehog 依赖性肿瘤的一个可成药靶点。
EMBO J. 2015 Jan 13;34(2):200-17. doi: 10.15252/embj.201489213. Epub 2014 Dec 4.
3
Expression of hedgehog signalling components in adult mouse testis.成年小鼠睾丸中刺猬信号通路成分的表达
Dev Dyn. 2006 Nov;235(11):3063-70. doi: 10.1002/dvdy.20931.
4
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.Gli转录因子在刺猬信号通路中的独特且互补的活性。
Exp Cell Res. 2006 Jul 1;312(11):1925-38. doi: 10.1016/j.yexcr.2006.02.019. Epub 2006 Mar 29.
5
Expression of Sonic hedgehog during cell proliferation in the human cerebellum.人小脑细胞增殖过程中 Sonic hedgehog 的表达。
Stem Cells Dev. 2012 May 1;21(7):1059-68. doi: 10.1089/scd.2011.0206. Epub 2011 Aug 24.
6
Heparanase-1 and components of the hedgehog signalling pathway are increased in untreated alveolar orbital rhabdomyosarcoma.未治疗的肺泡横纹肌肉瘤中肝素酶-1 和 hedgehog 信号通路的成分增加。
Clin Exp Ophthalmol. 2014 Mar;42(2):182-9. doi: 10.1111/ceo.12139. Epub 2013 Aug 4.
7
Cell signaling. A ciliary signaling switch.细胞信号传导。一种纤毛信号开关。
Science. 2007 Jul 20;317(5836):330-1. doi: 10.1126/science.1146180.
8
Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma.骨肉瘤中失调的刺猬信号通路的参与及靶向干预
Cancer. 2014 Feb 15;120(4):537-47. doi: 10.1002/cncr.28439. Epub 2013 Oct 21.
9
GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis.GLI3依赖的Gli1、Gli2和肾脏模式基因的转录抑制会破坏肾脏形态发生。
Development. 2006 Feb;133(3):569-78. doi: 10.1242/dev.02220. Epub 2006 Jan 5.
10
Hedgehog pathway gene expression during early development of the molar tooth root in the mouse.小鼠磨牙牙根早期发育过程中的刺猬信号通路基因表达
Gene Expr Patterns. 2007 Jan;7(3):239-43. doi: 10.1016/j.modgep.2006.10.001. Epub 2006 Oct 7.

引用本文的文献

1
Hedgehog and PI3K/Akt/mTOR Signaling Pathways Involvement in Leukemic Malignancies: Crosstalk and Role in Cell Death.刺猬信号通路和PI3K/Akt/mTOR信号通路在白血病恶性肿瘤中的作用：相互作用及在细胞死亡中的作用
Cells. 2025 Feb 13;14(4):269. doi: 10.3390/cells14040269.
2
Molecular insights into the hedgehog signaling pathway correlated non-coding RNAs in acute lymphoblastic leukemia, a bioinformatics study.急性淋巴细胞白血病中刺猬信号通路相关非编码RNA的分子见解：一项生物信息学研究
Ann Hematol. 2024 Dec;103(12):5439-5447. doi: 10.1007/s00277-024-05763-3. Epub 2024 Sep 3.
3
Understanding the Roles of the Hedgehog Signaling Pathway during T-Cell Lymphopoiesis and in T-Cell Acute Lymphoblastic Leukemia (T-ALL).理解 Hedgehog 信号通路在 T 细胞淋巴生成和 T 细胞急性淋巴细胞白血病（T-ALL）中的作用。
Int J Mol Sci. 2023 Feb 3;24(3):2962. doi: 10.3390/ijms24032962.
4
Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling. Hedgehog 信号通路：连接胚胎肺发育和哮喘气道重塑。
Cells. 2022 May 28;11(11):1774. doi: 10.3390/cells11111774.
5
Myeloid cell-based delivery of IFN-γ reprograms the leukemia microenvironment and induces anti-tumoral immune responses.基于髓系细胞的 IFN-γ 递送重编程白血病微环境并诱导抗肿瘤免疫反应。
EMBO Mol Med. 2021 Oct 7;13(10):e13598. doi: 10.15252/emmm.202013598. Epub 2021 Aug 30.
6
Medulloblastoma drugs in development: Current leads, trials and drawbacks.正在开发的髓母细胞瘤药物：现有先导物、临床试验和缺陷。
Eur J Med Chem. 2021 Apr 5;215:113268. doi: 10.1016/j.ejmech.2021.113268. Epub 2021 Feb 8.
7
Crosstalk between Hedgehog pathway and the glucocorticoid receptor pathway as a basis for combination therapy in T-cell acute lymphoblastic leukemia.Hedgehog 通路与糖皮质激素受体通路的相互作用是 T 细胞急性淋巴细胞白血病联合治疗的基础。
Oncogene. 2020 Oct;39(42):6544-6555. doi: 10.1038/s41388-020-01453-2. Epub 2020 Sep 11.
8
The Posterior Signaling Center Is an Important Microenvironment for Homeostasis of the Lymph Gland.后部信号中心是淋巴腺稳态的重要微环境。
Front Cell Dev Biol. 2020 May 21;8:382. doi: 10.3389/fcell.2020.00382. eCollection 2020.
9
The Bone Marrow Niche - The Tumor Microenvironment That Ensures Leukemia Progression.骨髓微环境——确保白血病进展的肿瘤微环境。
Adv Exp Med Biol. 2020;1219:259-293. doi: 10.1007/978-3-030-34025-4_14.
10
Inhibition of hedgehog signaling by stereochemically defined des-triazole itraconazole analogues.立体化学定义的去三唑伊曲康唑类似物抑制 Hedgehog 信号通路。
Bioorg Med Chem Lett. 2020 Jan 15;30(2):126794. doi: 10.1016/j.bmcl.2019.126794. Epub 2019 Nov 9.

本文引用的文献

1
Roles for Hedgehog signaling in adult organ homeostasis and repair.刺猬信号通路在成体器官稳态与修复中的作用。
Development. 2014 Sep;141(18):3445-57. doi: 10.1242/dev.083691.
2
The genomic landscape of hypodiploid acute lymphoblastic leukemia.低倍体急性淋巴细胞白血病的基因组景观。
Nat Genet. 2013 Mar;45(3):242-52. doi: 10.1038/ng.2532. Epub 2013 Jan 20.
3
Down-regulation of specific miRNAs enhances the expression of the gene Smoothened and contributes to T-cell lymphoblastic lymphoma development.下调特定的 miRNAs 可增强 Smoothened 基因的表达，促进 T 细胞淋巴母细胞淋巴瘤的发展。
Carcinogenesis. 2013 Apr;34(4):902-8. doi: 10.1093/carcin/bgs404. Epub 2013 Jan 3.
4
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia.外显子组测序鉴定出 T 细胞急性淋巴细胞白血病中 CNOT3 基因和核糖体基因 RPL5、RPL10 的突变。
Nat Genet. 2013 Feb;45(2):186-90. doi: 10.1038/ng.2508. Epub 2012 Dec 23.
5
Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926.急性淋巴细胞白血病细胞的自我更新受到 Hedgehog 通路抑制剂 cyclopamine 和 IPI-926 的限制。
PLoS One. 2010 Dec 28;5(12):e15262. doi: 10.1371/journal.pone.0015262.
6
Hedgehog beyond medulloblastoma and basal cell carcinoma.髓母细胞瘤和基底细胞癌之外的刺猬信号通路。
Biochim Biophys Acta. 2010 Apr;1805(2):181-208. doi: 10.1016/j.bbcan.2010.01.003. Epub 2010 Jan 18.
7
Hedgehog signaling is dispensable for adult hematopoietic stem cell function.刺猬信号通路对于成体造血干细胞功能并非必需。
Cell Stem Cell. 2009 Jun 5;4(6):548-58. doi: 10.1016/j.stem.2009.03.015.
8
Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation.印度刺猬因子（Ihh）既能促进也能限制胸腺细胞分化。
Blood. 2009 Mar 5;113(10):2217-28. doi: 10.1182/blood-2008-03-144840. Epub 2008 Dec 23.
9
Hedgehog regulates smoothened activity by inducing a conformational switch.刺猬索尼克蛋白通过诱导构象转换来调节平滑蛋白的活性。
Nature. 2007 Nov 8;450(7167):252-8. doi: 10.1038/nature06225. Epub 2007 Oct 24.
10
Sonic hedgehog signalling in T-cell development and activation.音猬因子信号通路在T细胞发育和激活中的作用
Nat Rev Immunol. 2007 Sep;7(9):726-35. doi: 10.1038/nri2151. Epub 2007 Aug 10.