Hedgehog pathway mutations in T-cell acute lymphoblastic leukemia.
作者信息
Dagklis Antonis, Pauwels Daphnie, Lahortiga Idoya, Geerdens Ellen, Bittoun Emilie, Cauwelier Barbara, Tousseyn Thomas, Uyttebroeck Anne, Maertens Johan, Verhoef Gregor, Vandenberghe Peter, Cools Jan
机构信息
Center for the Biology of the Disease, VIB, Leuven Center for Human Genetics, KU Leuven.
Department of Pathology UZ Leuven.
出版信息
Haematologica. 2015 Mar;100(3):e102-5. doi: 10.3324/haematol.2014.119248. Epub 2014 Dec 19.
Abstract
摘要
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本文引用的文献
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The genomic landscape of hypodiploid acute lymphoblastic leukemia.低倍体急性淋巴细胞白血病的基因组景观。
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Down-regulation of specific miRNAs enhances the expression of the gene Smoothened and contributes to T-cell lymphoblastic lymphoma development.下调特定的 miRNAs 可增强 Smoothened 基因的表达，促进 T 细胞淋巴母细胞淋巴瘤的发展。
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Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926.急性淋巴细胞白血病细胞的自我更新受到 Hedgehog 通路抑制剂 cyclopamine 和 IPI-926 的限制。
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