2-萘酚水平与儿童过敏症。
2-Naphthol Levels and Allergic Disorders in Children.
机构信息
Department of Neurosurgery, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.
Graduate Institute of Sports Science, College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan 333, Taiwan.
出版信息
Int J Environ Res Public Health. 2018 Jul 9;15(7):1449. doi: 10.3390/ijerph15071449.
BACKGROUND
The measurement of polycyclic aromatic hydrocarbons (PAH) in ambient air is quite difficult to perform. Using urine biomarkers of PAH such as 2-naphthol is one approach to this problem. This study explored the association between urine 2-naphthol levels and allergic diseases. The associations between 2-naphthol levels and oxidative stress biomarkers for the possible disease pathogenesis were also investigated.
METHOD
A total of 453 kindergarten children from the (Childhood Environment and Allergic Diseases Study) CEAS cohort with urine samples were recruited. Urine 2-naphthol levels were measured by high-performance liquid chromatography mass spectrometry (HPLC-MS/MS) and markers of oxidative stress (8OHdG) were measured by enzyme-linked immunosorbent assays (ELISA). Information on environmental risk factors and allergic diseases were also collected. The association between 2-naphthol levels, 8OHdG levels, IgE, and allergic diseases were evaluated by multivariate linear regression and logistic regression.
RESULTS
Levels of 2-naphthol were positively correlated with 8OHdG levels. A one ln-unit increase in the 2-naphthol level was positively associated to 8OHdG levels (per ln-unit: β = 100.61, p < 0.001). When dividing 2-naphthol levels into quartiles, asthma was significantly associated with 2-naphthol levels at a concentration of >1.60 ng/mL (adjusted OR: 3.14, 95% CI 1.34⁻7.35).
CONCLUSION
Urine 2-naphthol levels are associated with markers of oxidative stress and the risk of allergic diseases in young children.
背景
环境空气中多环芳烃（PAH）的测量相当困难。使用尿液中 PAH 的生物标志物，如 2-萘酚，是解决此问题的一种方法。本研究探讨了尿液 2-萘酚水平与过敏性疾病之间的关系。还研究了 2-萘酚水平与氧化应激生物标志物之间的关联，以探讨可能的疾病发病机制。
方法
共招募了来自（儿童环境与过敏性疾病研究）CEAS 队列的 453 名幼儿园儿童，他们有尿液样本。采用高效液相色谱-质谱联用（HPLC-MS/MS）法测定尿液 2-萘酚水平，采用酶联免疫吸附试验（ELISA）法测定氧化应激标志物（8OHdG）。还收集了环境危险因素和过敏性疾病的信息。采用多元线性回归和逻辑回归评估 2-萘酚水平、8OHdG 水平、IgE 与过敏性疾病之间的关系。
结果
2-萘酚水平与 8OHdG 水平呈正相关。2-萘酚水平每增加一个 ln 单位与 8OHdG 水平呈正相关（每 ln 单位：β=100.61，p<0.001）。当将 2-萘酚水平分为四等分时，哮喘与浓度>1.60ng/mL 的 2-萘酚水平显著相关（调整后的 OR：3.14，95%CI 1.34⁻7.35）。
结论
尿液 2-萘酚水平与氧化应激标志物和幼儿过敏性疾病的风险相关。
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