Imbri Dennis, Tauber Johannes, Opatz Till
Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.
Mar Drugs. 2014 Dec 18;12(12):6142-77. doi: 10.3390/md12126142.
The present review discusses the known synthetic routes to the lamellarin alkaloids published until 2014. It begins with syntheses of the structurally simpler type-II lamellarins and then focuses on the larger class of the 5,6-saturated and -unsaturated type-I lamellarins. The syntheses are grouped by the strategy employed for the assembly of the central pyrrole ring.
本综述讨论了截至2014年已发表的海兔毒素生物碱的已知合成路线。它首先介绍结构较简单的II型海兔毒素的合成,然后重点关注更大类别的5,6-饱和和不饱和I型海兔毒素。这些合成方法根据构建中心吡咯环所采用的策略进行分类。