Yardimci Ibrahim, Karakan Tolga, Resorlu Berkan, Doluoglu Omer Gokhan, Ozcan Serkan, Aydın Arif, Demirbas Arif, Unverdi Hatice, Eroglu Muzaffer
Department of Urology, Ankara Education and Research Hospital, Ankara, Turkey.
Department of Urology, Ankara Education and Research Hospital, Ankara, Turkey.
Urology. 2015 Jan;85(1):274.e9-13. doi: 10.1016/j.urology.2014.09.038.
To determine the efficacy of dexpanthenol applied early after urethral trauma for preventing inflammation and spongiofibrosis.
Twenty-seven rats were randomized and divided into 3 groups, with 9 rats in each group. The urethras of all rats were traumatized with a pediatric urethrotome knife at 6-o' clock. For 14 days, group I was given 0.9% saline twice a day (control group), group II was given dexpanthenol 500 mg/kg ampules once a day and 0.9% saline once a day, and group III was given dexpanthenol 500 mg/kg ampules twice a day intraurethrally using a 22 ga catheter sheath. On day 15, the penises of the rats were degloved to perform penectomy.
The mean fibrosis scores were 2.4, 2.2, and 1.4, and mean inflammation scar scores were 2, 1.4, and 1.3 in groups I, II, and III, respectively. There was a significant difference between groups I and II for inflammation (P = .011); however, the difference for fibrosis was not significant (P = .331). The differences between groups I and III were statistically significantly different both for inflammation and fibrosis (P = .004 and P = .003, respectively). Groups II and III were not different significantly for inflammation (P = .638); however, there was less fibrosis in group III, in which high-dose dexpanthenol was administered.
We showed that dexpanthenol applied early after urethral trauma significantly decreased inflammation and spongiofibrosis. We hope that our study will help to decrease strictures after urethral trauma and contribute to pharmaceutical investigations aiming to improve the success of the surgery for urethral strictures.
确定尿道创伤后早期应用泛醇预防炎症和海绵体纤维化的疗效。
将27只大鼠随机分为3组，每组9只。所有大鼠的尿道于6点位置用小儿尿道刀造成创伤。第1组每天给予2次0.9%生理盐水（对照组），共14天；第2组每天给予1次500mg/kg安瓿剂泛醇和1次0.9%生理盐水；第3组使用22号导管鞘每天经尿道给予2次500mg/kg安瓿剂泛醇。在第15天，将大鼠阴茎皮肤剥脱后进行阴茎切除。
第1、2、3组的平均纤维化评分分别为2.4、2.2和1.4，平均炎症瘢痕评分分别为2、1.4和1.3。第1组和第2组在炎症方面有显著差异（P = 0.011）；然而，在纤维化方面差异不显著（P = 0.331）。第1组和第3组在炎症和纤维化方面的差异均有统计学意义（分别为P = 0.004和P = 0.003）。第2组和第3组在炎症方面无显著差异（P = 0.638）；然而，给予高剂量泛醇的第3组纤维化程度较轻。
我们发现尿道创伤后早期应用泛醇可显著减轻炎症和海绵体纤维化。我们希望我们的研究将有助于减少尿道创伤后的狭窄，并有助于旨在提高尿道狭窄手术成功率的药物研究。
