Yelsel Kazım, Alma Ergün, Yüceer Ömer, Taş Zeynel Abidin, Totan Ateş Berna, Kobaner Murat, Esimek Halil, Altunkol Adem, Ünal Umut, Ayyıldız Ali
Clinic of Urology, Adana Yüreğir State Hospital, Adana, Türkiye.
Clinic of Urology, Adana City Training and Research Hospital, Adana, Türkiye.
Urol Res Pract. 2025 Jan 3;50(4):261-266. doi: 10.5152/tud.2025.24068.
The aim was to evaluate the effect of yellow and red centaury St. John's Wort (St. JW) oil on inflammation and urethral fibrosis development in a rat urethral trauma model.
A total of 24 male rats were divided into 5 groups. No urethral damage was induced in the sham group. The urethras of all rats in the other groups was traumatized at 6 o'clock with a specially designed urethrotome blade. Group 1 was administered 0.5 cc of St. JW oil once daily for 15 days. Group 2 was administered 0.5 cc of red centaury oil intraurethrally once daily for 15 days. The traumatized rats in Group 3 were not treated (St. JW and red centaury oil were not administered). St. JW oil was administered to 3 rats in the Sham 1 group (Group 4), and red centaury oil was administered to 3 rats in the Sham 2 group (Group 5). A 20-G/32-mm intravenous cannula sheath was used for intraurethral administration. On the 15th day, rats were sacrificed and penectomy was performed for histologic evaluation.
Spongiofibrosis, mucosal inflammation, and congestion were significantly decreased in the yellow St. JW oil group when compared with the red centaury oil group and the untreated group (group to which neither St. JW nor red centaury oil was administered).
In this study, intraurethral administration of yellow St. JW oil was found to significantly reduce mucosal inflammation, spongiofibrosis, and obstruction after urethral trauma. According to the results of this study, we think that St. JW oil may be a promising option in the treatment of urethral stricture.
本研究旨在评估金丝桃属植物贯叶连翘（圣约翰草，St. JW）的黄色和红色提取物油对大鼠尿道创伤模型中炎症和尿道纤维化发展的影响。
将24只雄性大鼠分为5组。假手术组未诱导尿道损伤。其他组所有大鼠的尿道在6点位置用特制的尿道切开刀造成创伤。第1组每天一次给予0.5 cc的圣约翰草提取物油，持续15天。第2组每天一次经尿道给予0.5 cc的红色金丝桃提取物油，持续15天。第3组的创伤大鼠未接受治疗（未给予圣约翰草提取物油和红色金丝桃提取物油）。在假手术1组（第4组）的3只大鼠中给予圣约翰草提取物油，在假手术2组（第5组）的3只大鼠中给予红色金丝桃提取物油。经尿道给药使用20-G/32-mm静脉套管鞘。在第15天，处死大鼠并进行阴茎切除以进行组织学评估。
与红色金丝桃提取物油组和未治疗组（未给予圣约翰草提取物油和红色金丝桃提取物油的组）相比，黄色圣约翰草提取物油组的海绵体纤维化、黏膜炎症和充血明显减轻。
在本研究中，发现经尿道给予黄色圣约翰草提取物油可显著减轻尿道创伤后的黏膜炎症、海绵体纤维化和梗阻。根据本研究结果，我们认为圣约翰草提取物油可能是治疗尿道狭窄的一个有前景的选择。
