Oguz Abdullah, Uslukaya Omer, Alabalık Ulas, Turkoglu Ahmet, Kapan Murat, Bozdag Zubeyir
1 Department of General Surgery, Dicle University Medical Faculty, Diyarbakır, Turkey.
Int Surg. 2015 Apr;100(4):656-61. doi: 10.9738/INTSURG-D-14-00227.1. Epub 2015 Jan 13.
In this study, we aimed to compare the effects of dexpanthenol and N-acetylcysteine on wound healing. The wound healing process is a multifaceted sequence of activities associated with tissue restoration process. A number of investigations and clinical studies have been performed to determine new approaches for the improvement of wound healing. A total of 30 rats were divided into 3 equal groups. A linear 2-cm incision was made in the rats' skin. No treatment was administered in the first (control) group. Dexpanthenol cream was administered to the rats in the second group and 3% N-acetylcysteine cream was administered to the rats in the third group. The wound areas of all of the rats were measured on certain days. On the 21st day, all wounds were excised and histologically evaluated. The epithelialization and granulation rates between the groups were revealed to be similar in microscopic evaluations. Although the fibrosis was remarkable in the control group as compared with the other groups, it was similar in N-acetylcysteine and dexpanthenol groups. Angiogenesis rate was remarkable in the N-acetylcysteine group compared with the others. In multiple-comparison analysis, Dexpanthenol and N-acetylcysteine groups had similar results in terms of wound healing rates (P < 0.05), which were both higher than in the control group (P > 0.05). The efficacy of N-acetylcysteine in wound healing is comparable to dexpanthenol, and both substances can be used to improve wound healing.
在本研究中，我们旨在比较泛醇和N-乙酰半胱氨酸对伤口愈合的影响。伤口愈合过程是与组织修复过程相关的一系列多方面的活动。已经进行了多项调查和临床研究以确定改善伤口愈合的新方法。总共30只大鼠被分成3个相等的组。在大鼠皮肤上做一个2厘米长的线性切口。第一组（对照组）不进行治疗。给第二组大鼠涂抹泛醇乳膏，给第三组大鼠涂抹3%的N-乙酰半胱氨酸乳膏。在特定的日子测量所有大鼠的伤口面积。在第21天，切除所有伤口并进行组织学评估。在显微镜评估中，各组之间的上皮化和肉芽形成率显示相似。与其他组相比，对照组的纤维化明显，但N-乙酰半胱氨酸组和泛醇组相似。与其他组相比，N-乙酰半胱氨酸组的血管生成率明显。在多重比较分析中，泛醇组和N-乙酰半胱氨酸组在伤口愈合率方面结果相似（P<0.05），两者均高于对照组（P>0.05）。N-乙酰半胱氨酸在伤口愈合方面的疗效与泛醇相当，两种物质均可用于改善伤口愈合。
