Ma Cheng, Xu Xiao, Liu Yan, Wang Lihong V
Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130-4899.
Nat Photonics. 2014 Dec;8(12):931-936. doi: 10.1038/nphoton.2014.251.
The ability to steer and focus light inside scattering media has long been sought for a multitude of applications. To form optical foci inside scattering media, the only feasible strategy at present is to guide photons by using either implanted or virtual guide stars, which can be inconvenient and limits potential applications. Here, we report a scheme for focusing light inside scattering media by employing intrinsic dynamics as guide stars. By time-reversing the perturbed component of the scattered light adaptively, we show that it is possible to focus light to the origin of the perturbation. Using the approach, we demonstrate non-invasive dynamic light focusing onto moving targets and imaging of a time-variant object obscured by highly scattering media. Anticipated applications include imaging and photoablation of angiogenic vessels in tumours as well as other biomedical uses.
长期以来，人们一直在寻求在散射介质中操纵和聚焦光的能力，以用于众多应用。要在散射介质中形成光学焦点，目前唯一可行的策略是使用植入式或虚拟导星来引导光子，这可能不方便且限制了潜在应用。在此，我们报告了一种通过利用固有动力学作为导星在散射介质中聚焦光的方案。通过自适应地对散射光的扰动分量进行时间反转，我们表明可以将光聚焦到扰动源。使用该方法，我们展示了对移动目标的非侵入式动态光聚焦以及对被高散射介质遮挡的时变物体的成像。预期应用包括肿瘤中血管生成血管的成像和光消融以及其他生物医学用途。
