神经囊尾蚴病：癫痫发生的天然人类模型。
Neurocysticercosis: A natural human model of epileptogenesis.
机构信息
Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.
出版信息
Epilepsia. 2015 Feb;56(2):177-83. doi: 10.1111/epi.12849. Epub 2014 Dec 23.
Abstract
OBJECTIVE
To develop a better understanding of mechanisms of seizures and long-term epileptogenesis using neurocysticercosis.
METHODS
A workshop was held bringing together experts in epilepsy and epileptogenesis and neurocysticercosis.
RESULTS
Human neurocysticercosis and parallel animal models offer a unique opportunity to understand basic mechanisms of seizures. Inflammatory responses to degenerating forms and later-stage calcified parasite granulomas are associated with seizures and epilepsy. Other mechanisms may also be involved in epileptogenesis.
SIGNIFICANCE
Naturally occurring brain infections with neurocysticercosis offer a unique opportunity to develop treatments for one of the world's most common causes of epilepsy and for the development of more general antiepileptogenic treatments. Key advantages stem from the time course in which an acute seizure heralds a start of the epileptogenic process, and radiographic changes of calcification and perilesional edema provide biomarkers of a chronic epileptic state.
摘要
目的
利用神经囊虫病更好地了解癫痫发作和长期致痫的机制。
方法
举办了一次研讨会，汇集了癫痫和致痫以及神经囊虫病方面的专家。
结果
人类神经囊虫病和类似的动物模型为了解癫痫发作的基本机制提供了独特的机会。对变性和晚期钙化寄生虫肉芽肿的炎症反应与癫痫发作和癫痫有关。其他机制也可能参与致痫过程。
意义
神经囊虫病的自然发生的脑部感染为开发针对世界上最常见的癫痫病因之一的治疗方法以及开发更广泛的抗癫痫发作治疗方法提供了独特的机会。主要优势源于急性发作预示着致痫过程开始的时间过程，以及钙化和病变周围水肿的放射学变化为慢性癫痫状态提供了生物标志物。
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