Appleton K M, Grippo A J, Beltz T G, Johnson A K
Department of Psychology, The University of Iowa, Iowa City, IA, USA; School of Psychology, The Queen׳s University of Belfast, Belfast, UK.
Department of Psychology, Northern Illinois University, DeKalb, IL, USA.
Prostaglandins Leukot Essent Fatty Acids. 2015 Apr;95:11-8. doi: 10.1016/j.plefa.2014.11.010. Epub 2014 Dec 4.
n-3 Polyunsaturated fatty acids (n-3PUFAs) may be beneficial for anxiety and depression under stressful conditions. Studies however, typically utilise physical or sudden physiological stress, while gradual physiological stress is also relevant to human conditions. Using deoxycorticosterone acetate (DOCA) administration to induce gradual physiological stress, this study investigated the impact of n-3PUFAs under gradual physiological stress in rats. Animals (aged 2 months) (N=8-12/group) received daily injections of DOCA or vehicle and were concurrently fed a high n-3PUFA or control diet for eight weeks. Behavioural measures were taken throughout. Behavioural tests and physiological measures were conducted after six and eight weeks respectively. DOCA administration decreased plasma renin, plasma proteins and relative adrenal weight, and increased water intake, relative kidney weight, and anxiety in the open field. These findings demonstrate disruptions to the renin-angiotensin-aldosterone system, a result of mild physiological stress, that also impact on anxiety behaviours. No effects of n-3PUFAs were found.
n-3多不饱和脂肪酸（n-3PUFAs）在应激条件下可能对焦虑和抑郁有益。然而，研究通常使用身体或突然的生理应激，而逐渐的生理应激也与人类状况相关。本研究使用醋酸脱氧皮质酮（DOCA）给药诱导逐渐的生理应激，调查了n-3PUFAs在大鼠逐渐生理应激下的影响。动物（2个月龄）（每组N = 8 - 12只）每天注射DOCA或赋形剂，并同时喂食高n-3PUFA或对照饮食八周。全程进行行为测量。分别在六周和八周后进行行为测试和生理测量。给予DOCA会降低血浆肾素、血浆蛋白和相对肾上腺重量，并增加饮水量、相对肾脏重量以及旷场试验中的焦虑水平。这些发现表明轻度生理应激导致肾素-血管紧张素-醛固酮系统紊乱，这也会影响焦虑行为。未发现n-3PUFAs有作用。
