辛酸与甘油三硝酸酯联合用于生物膜根除
Caprylic acid and glyceryl trinitrate combination for eradication of biofilm.
作者信息
Rosenblatt Joel, Reitzel Ruth A, Raad Issam
机构信息
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
出版信息
Antimicrob Agents Chemother. 2015 Mar;59(3):1786-8. doi: 10.1128/AAC.04561-14. Epub 2014 Dec 22.
Abstract
There is a growing need for biocompatible, broad-spectrum, nonantibiotic, antimicrobial treatments because of the frequent ineffectiveness of antibiotics against biofilms and the increasing incidence of antibiotic resistance. In this study, we demonstrate rapid and complete biofilm eradication in an in vitro model with synergistic combinations of glyceryl trinitrate and caprylic acid against resistant Gram-positive, Gram-negative, and fungal biofilms.
摘要
由于抗生素对生物膜常常无效且抗生素耐药性的发生率不断上升，对生物相容性、广谱、非抗生素抗菌治疗的需求日益增长。在本研究中，我们证明了在体外模型中，硝酸甘油和辛酸的协同组合对耐药革兰氏阳性、革兰氏阴性和真菌生物膜具有快速且完全的生物膜根除效果。
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