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用硝酸甘油使医院病原体失活。

Silencing the nosocomial pathogen by glyceryl trinitrate.

作者信息

Abbas Hisham A, Elsherbini Ahmed M

机构信息

Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University- Zagazig- Egypt.

Health Sciences College-Umm Al Qura University, AlQunfudah, Saudi Arabia.

出版信息

Afr Health Sci. 2018 Mar;18(1):1-10. doi: 10.4314/ahs.v18i1.2.

DOI:10.4314/ahs.v18i1.2
PMID:29977251
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6016988/
Abstract

BACKGROUND

Quorum sensing is a cell-to-cell communication system in bacteria that controls the production of virulence factors. is a causative agent of hospital-acquired infections that shows high resistance to antibiotics. This makes the treatment of these infections difficult. Quorum sensing regulates the production of virulence factors of such as prodigiosin, protease, swimming and swarming motilities and formation of biofilms. Inhibition of quorum sensing may be an alternative to antibiotic treatment to avoid emergence of resistance.

OBJECTIVES

Testing the ability of glyceryl trinitrate to inhibit quorum sensing and virulence factors of .

METHODS

The inhibiting activities of sub-inhibitory concentration of glyceryl trinitrate against the quorum-sensing regulated violacein pigment in CV026 was performed to evaluate the anti-quorum sensing effect of glyceryl trinitrate. The anti-virulence activity was assessed against prodigiosin, protease, biofilm formation in addition to swimming and swarming motilities.

RESULTS

Glyceryl trinitrate at at a concentration of 0.25 mg/ml produced significant inhibitory effects against violacein (67.01%), prodigiosin (82.67%), protease, swimming (36.72%) and swarming (79.31%) motilities and biofilm formation (87.83%).

CONCLUSION

Glyceryl trinitrate is a quorum sensing and virulence inhibitor that may be useful in treatment of nosocomial infections caused by .

摘要

背景

群体感应是细菌中一种细胞间通讯系统，可控制毒力因子的产生。[细菌名称未给出]是医院获得性感染的病原体，对抗生素表现出高度耐药性。这使得这些感染的治疗变得困难。群体感应调节[细菌名称未给出]毒力因子的产生，如灵菌红素、蛋白酶、游动和群集运动以及生物膜的形成。抑制群体感应可能是抗生素治疗的替代方法，以避免耐药性的出现。

目的

测试硝酸甘油抑制[细菌名称未给出]群体感应和毒力因子的能力。

方法

通过检测亚抑菌浓度的硝酸甘油对[细菌名称未给出]CV026中群体感应调控的紫色杆菌素色素的抑制活性，评估硝酸甘油的抗群体感应效果。除了游动和群集运动外，还针对灵菌红素、蛋白酶、生物膜形成评估其抗毒力活性。

结果

浓度为0.25mg/ml的硝酸甘油对紫色杆菌素（67.01%）、灵菌红素（82.67%）、蛋白酶、游动（36.72%）和群集（79.31%）运动以及生物膜形成（87.83%）产生了显著抑制作用。

结论

硝酸甘油是一种群体感应和毒力抑制剂，可能对治疗由[细菌名称未给出]引起的医院感染有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/4e991e921038/AFHS1801-0001Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/c59e0de6d644/AFHS1801-0001Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/eed8215a6e37/AFHS1801-0001Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/0986c479f69f/AFHS1801-0001Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/46a8ed26aea0/AFHS1801-0001Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/40bac4c6c319/AFHS1801-0001Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/29368871cefa/AFHS1801-0001Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/054d38c0fee9/AFHS1801-0001Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/4e991e921038/AFHS1801-0001Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/c59e0de6d644/AFHS1801-0001Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/eed8215a6e37/AFHS1801-0001Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/0986c479f69f/AFHS1801-0001Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/46a8ed26aea0/AFHS1801-0001Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/40bac4c6c319/AFHS1801-0001Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/29368871cefa/AFHS1801-0001Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/054d38c0fee9/AFHS1801-0001Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea6/6016988/4e991e921038/AFHS1801-0001Fig8.jpg

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