微小外显子——微小却强大。
Microexons--tiny but mighty.
机构信息
Laboratory of Molecular Neuro-Oncology and Howard Hughes Medical Institute The Rockefeller University, New York, NY, USA.
Laboratory of Molecular Neuro-Oncology and Howard Hughes Medical Institute The Rockefeller University, New York, NY, USA New York Genome Center, New York, NY, USA.
出版信息
EMBO J. 2015 Feb 3;34(3):273-4. doi: 10.15252/embj.201490651. Epub 2014 Dec 22.
Abstract
The landscape of alternative splicing is only beginning to unravel, and the functional consequences are often unclear. Two articles in and focus on a set of largely ignored yet highly conserved exons, microexons. These appear strongly regulated by RNA-binding proteins (RBPs) and functionally modulate protein–protein interactions with strong evidence for deregulation in autism spectrum disorder.
摘要
外显子剪接的格局才刚刚开始被揭示，其功能后果往往还不清楚。本期的两篇文章聚焦于一组很大程度上被忽视但却高度保守的外显子，即 microexon。microexon 似乎受到 RNA 结合蛋白 (RBP) 的强烈调控，并且能够调节蛋白质-蛋白质相互作用，在自闭症谱系障碍中存在明显失调的证据。
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2
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本文引用的文献
1
A highly conserved program of neuronal microexons is misregulated in autistic brains.在自闭症大脑中，一个高度保守的神经元微小外显子程序受到了失调调控。
Cell. 2014 Dec 18;159(7):1511-23. doi: 10.1016/j.cell.2014.11.035.
2
RBFOX and PTBP1 proteins regulate the alternative splicing of micro-exons in human brain transcripts.RBFOX和PTBP1蛋白调节人类大脑转录本中微小外显子的可变剪接。
Genome Res. 2015 Jan;25(1):1-13. doi: 10.1101/gr.181990.114.
3
A global regulatory mechanism for activating an exon network required for neurogenesis.一个用于激活神经发生所需外显子网络的全球调控机制。
Mol Cell. 2014 Oct 2;56(1):90-103. doi: 10.1016/j.molcel.2014.08.011. Epub 2014 Sep 11.
4
HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism.HITS-CLIP技术与整合模型确定了与大脑发育和自闭症相关的Rbfox剪接调控网络。
Cell Rep. 2014 Mar 27;6(6):1139-1152. doi: 10.1016/j.celrep.2014.02.005. Epub 2014 Mar 6.
5
De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function.PTBP1结合与剪接靶点的从头预测揭示了其RNA识别和功能的意外特征。
PLoS Comput Biol. 2014 Jan 30;10(1):e1003442. doi: 10.1371/journal.pcbi.1003442. eCollection 2014 Jan.
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Identification and characterization of a neuron-specific isoform of protrudin.鉴定和描述一种突起蛋白的神经元特异性同工型。
Genes Cells. 2014 Feb;19(2):97-111. doi: 10.1111/gtc.12109. Epub 2013 Nov 20.
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RNA protein interaction in neurons.神经元中的 RNA 蛋白相互作用。
Annu Rev Neurosci. 2013 Jul 8;36:243-70. doi: 10.1146/annurev-neuro-062912-114322. Epub 2013 May 20.
8
Tissue-specific alternative splicing remodels protein-protein interaction networks.组织特异性可变剪接重塑蛋白质-蛋白质相互作用网络。
Mol Cell. 2012 Jun 29;46(6):884-92. doi: 10.1016/j.molcel.2012.05.037.
9
Alternative splicing: decoding an expansive regulatory layer.选择性剪接：解码扩展性调控层。
Curr Opin Cell Biol. 2012 Jun;24(3):323-32. doi: 10.1016/j.ceb.2012.03.005. Epub 2012 Mar 30.
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Microexon-based regulation of ITSN1 and Src SH3 domains specificity relies on introduction of charged amino acids into the interaction interface.基于微外显子的 ITSN1 和 Src SH3 结构域特异性调节依赖于将带电荷的氨基酸引入相互作用界面。
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