Laboratory of Molecular Neuro-Oncology and Howard Hughes Medical Institute The Rockefeller University, New York, NY, USA.
Laboratory of Molecular Neuro-Oncology and Howard Hughes Medical Institute The Rockefeller University, New York, NY, USA New York Genome Center, New York, NY, USA.
EMBO J. 2015 Feb 3;34(3):273-4. doi: 10.15252/embj.201490651. Epub 2014 Dec 22.
The landscape of alternative splicing is only beginning to unravel, and the functional consequences are often unclear. Two articles in and focus on a set of largely ignored yet highly conserved exons, microexons. These appear strongly regulated by RNA-binding proteins (RBPs) and functionally modulate protein–protein interactions with strong evidence for deregulation in autism spectrum disorder.
外显子剪接的格局才刚刚开始被揭示，其功能后果往往还不清楚。本期的两篇文章聚焦于一组很大程度上被忽视但却高度保守的外显子，即 microexon。microexon 似乎受到 RNA 结合蛋白 (RBP) 的强烈调控，并且能够调节蛋白质-蛋白质相互作用，在自闭症谱系障碍中存在明显失调的证据。
