Murthy Tvsp
Department of Anesthesia and Crtical Care, Command Hospital, Armed Forces Medical College, Pune, Maharashtra, India.
Indian J Anaesth. 2014 Sep;58(5):643-6. doi: 10.4103/0019-5049.144676.
Sepsis is a clinical syndrome characterised by systemic inflammation due to infection. There is a spectrum with severity ranging from sepsis to severe sepsis and septic shock. Even with optimal treatment, mortality due to severe sepsis or septic shock is significant and poses a challenge to management. Antibiotics, source control, resuscitation with fluids, vasopressor and inotropic agents are the main-stay of treatment for septic shock. These may be supplemented with transfusion of red blood cells and or blood products, in the case of anaemia to sustain sufficient oxygen delivery([1]) or to manage associated haematological issues. Transfusion in sepsis has always been a debatable issue, especially in relation to choice of the fluid and the role of blood or blood product transfusion.
脓毒症是一种因感染导致全身炎症反应的临床综合征。其严重程度呈谱状分布，从脓毒症到严重脓毒症及脓毒性休克。即便采用最佳治疗，严重脓毒症或脓毒性休克导致的死亡率仍很高，给治疗带来挑战。抗生素、源头控制、液体复苏、血管活性药物和正性肌力药物是脓毒性休克治疗的主要手段。对于贫血患者，为维持足够的氧输送（[1]）或处理相关血液学问题，可补充输注红细胞和/或血液制品。脓毒症中的输血一直是个有争议的问题，尤其是在液体选择以及血液或血液制品输血的作用方面。
