过敏性紫癜患儿氧化应激及红细胞特性评估
Evaluation of oxidative stress and erythrocyte properties in children with henoch-shoenlein purpura.
作者信息
Gurses Dolunay, Parlaz Nusret, Bor-Kucukatay Melek, Kucukatay Vural, Erken Gulten
机构信息
Department of Pediatrics.
Department of Physiology, Pamukkale University Faculty of Medicine , Denizli, Turkey.
出版信息
Iran J Pediatr. 2014 Apr;24(2):166-72.
OBJECTIVE
Pathogenesis of Henoch-Schönlein purpura (HSP) is not clearly defined. The present study was conducted to investigate the alterations in erythrocyte deformability and oxidative stress in HSP and to examine the possible relationship between erythrocyte deformability and organ involvement in this disease.
METHODS
Plasma malondialdehyde (MDA) levels, total antioxidant status (TAS), erythrocyte deformability and aggregation were measured in 21 children with HSP at the disease onset and during the remission period in comparison with healthy subjects.
FINDINGS
HSP patients at the active stage had significantly higher MDA and lower TAS levels (P<0.05). Erythrocyte deformability was decreased at the active-stage and increased again at the remission period of HSP (P<0.05). Erythrocyte deformability was significantly decreased at four different shear stresses in patients with gastrointestinal system or renal involvement; and decreased at six different shear stresses in patients with gastrointestinal system, and renal involvement compared to the patients without organ involvement (P<0.05). No significant difference was observed in aggregation parameters (P>0.05).
CONCLUSION
The present findings emphasize the association between impaired erythrocyte deformability and organ involvement in HSP.
目的
过敏性紫癜（HSP）的发病机制尚未明确。本研究旨在调查HSP患者红细胞变形性和氧化应激的变化，并探讨红细胞变形性与该疾病器官受累之间的可能关系。
方法
测量21例HSP患儿发病时及缓解期的血浆丙二醛（MDA）水平、总抗氧化状态（TAS）、红细胞变形性和聚集性，并与健康受试者进行比较。
结果
活动期HSP患者的MDA水平显著升高，TAS水平显著降低（P<0.05）。HSP活动期红细胞变形性降低，缓解期再次升高（P<0.05）。胃肠道或肾脏受累患者在四种不同切变应力下红细胞变形性显著降低；与无器官受累患者相比，胃肠道和肾脏受累患者在六种不同切变应力下红细胞变形性降低（P<0.05）。聚集参数无显著差异（P>0.05）。
结论
本研究结果强调了红细胞变形性受损与HSP器官受累之间的关联。
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