Demircin G, Oner A, Unver Y, Bülbül M, Erdoğan O
Dr Sami Ulus Children's Hospital, Department of Nephrology, Ankara, Turkey.
Acta Paediatr. 1998 Aug;87(8):848-52. doi: 10.1080/080352598750013617.
Reactive oxygen molecules (ROM) have been suggested to contribute to many pathological conditions including vasculitides and renal diseases. In the present study we measured the activity of superoxide dismutase (SOD) as an antioxidant enzyme in red blood cells and the level of malondialdehyde (MDA), which is a product and an indicator of lipid peroxidation, in the plasma of 16 children (7M, 9F) with Henoch Schönlein purpura (HSP) at the onset of the disease (SOD 1 and MDA 1) and at the remission period (SOD 2 and MDA 2). The results were compared with the results of 17 healthy children studied as a control group. There was no significant difference for SOD activities between the patients in each period and the control group (p > 0.05). There was a statistically significant difference between MDA 1 and MDA 2 levels (p < 0.01), each of which were also significantly different from the MDA levels of control group (p < 0.001 and p < 0.01, respectively). The effect of ROMs on different clinical conditions of HSP was also examined and lipid peroxidation was found to be increased more in patients with renal involvement. It is concluded that oxidant stress especially lipid peroxidation plays an important role in the pathogenesis of HSP and in development of renal injury.
活性氧分子（ROM）被认为与包括血管炎和肾脏疾病在内的多种病理状况有关。在本研究中，我们测量了16名患有过敏性紫癜（HSP）的儿童（7名男性，9名女性）在疾病发作时（SOD 1和MDA 1）以及缓解期（SOD 2和MDA 2）红细胞中作为抗氧化酶的超氧化物歧化酶（SOD）的活性，以及血浆中作为脂质过氧化产物和指标的丙二醛（MDA）的水平。将结果与作为对照组的17名健康儿童的结果进行比较。各时期患者与对照组之间的SOD活性无显著差异（p>0.05）。MDA 1和MDA 2水平之间存在统计学显著差异（p<0.01），且它们各自与对照组的MDA水平也有显著差异（分别为p<0.001和p<0.01）。还研究了ROM对HSP不同临床状况的影响，发现肾脏受累患者的脂质过氧化增加更为明显。结论是氧化应激尤其是脂质过氧化在HSP的发病机制和肾损伤的发展中起重要作用。
