a Biochemistry Section, Department of Drug Sciences , University of Catania , V.le A. Doria 6, 95125 Catania , Italy.
Nat Prod Res. 2015;29(17):1630-40. doi: 10.1080/14786419.2014.994212. Epub 2014 Dec 24.
The objectives of our research were to study the chemical composition and the in vitro anticancer effect of the essential oil of Salvia verbenaca growing in natural sites in comparison with those of cultivated (Sc) plants. The oil from wild (Sw) S. verbenaca presented hexadecanoic acid (23.1%) as the main constituent, while the oil from Sc plants contained high quantities of hexahydrofarnesyl acetone (9.7%), scarce in the natural oil (0.7%). The growth-inhibitory and proapoptotic effects of the essential oils from Sw and Sc S. verbenaca were evaluated in the human melanoma cell line M14, testing cell vitality, cell membrane integrity, genomic DNA fragmentation and caspase-3 activity. Both the essential oils were able to inhibit the growth of the cancer cells examined inducing also apoptotic cell death, but the essential oil from cultivated samples exhibited the major effects.
我们研究的目的是研究生长在自然环境中的马鞭草精油的化学成分和体外抗癌作用，并与人工种植（Sc）植物进行比较。野生（Sw）马鞭草精油的主要成分是十六烷酸（23.1%），而 Sc 植物精油则含有大量的六氢法呢基丙酮（9.7%），在天然油中含量很少（0.7%）。评估了 Sw 和 Sc 马鞭草精油对人黑色素瘤细胞系 M14 的生长抑制和促凋亡作用，检测细胞活力、细胞膜完整性、基因组 DNA 片段化和 caspase-3 活性。两种精油都能抑制所检测癌细胞的生长，同时诱导细胞凋亡，但来自人工种植样本的精油表现出更大的作用。
