Eap Sandy, Morand David, Clauss François, Huck Olivier, Stoltz Jean-François, Lutz Jean-Christophe, Gottenberg Jacques-Eric, Benkirane-Jessel Nadia, Keller Laetitia, Fioretti Florence
French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Faculté de Médecine, Strasbourg, France.
French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Faculté de Médecine, Strasbourg, France Université de Strasbourg, Faculté de Chirurgie Dentaire, Strasbourg, France.
Biomed Mater Eng. 2015;25(1 Suppl):79-85. doi: 10.3233/BME-141248.
Designing unique nanostructured biomimetic materials is a new challenge in modern regenerative medicine. In order to develop functional substitutes for damaged organs or tissues, several methods have been used to create implants able to regenerate robust and durable bone. Electrospinning produces nonwoven scaffolds based on polymer nanofibers mimicking the fibrillar organization of bone extracellular matrix. Here, we describe a biomimetic 3D thick nanofibrous scaffold obtained by electrospinning of the biodegradable, bioresorbable and FDA-approved polymer, poly(ε-caprolactone). Such scaffold presents a thickness reaching one centimeter. We report here the demonstration that the designed nanostructured implant is able to induce in vivo bone regeneration.
设计独特的纳米结构仿生材料是现代再生医学面临的一项新挑战。为了开发受损器官或组织的功能性替代物，人们已经采用了多种方法来制造能够再生坚固耐用骨骼的植入物。静电纺丝基于聚合物纳米纤维制造非织造支架，模仿骨细胞外基质的纤维组织。在此，我们描述了一种通过静电纺丝可生物降解、可生物吸收且经美国食品药品监督管理局批准的聚合物聚（ε-己内酯）获得的仿生三维厚纳米纤维支架。这种支架的厚度可达一厘米。我们在此报告所设计的纳米结构植入物能够在体内诱导骨再生的论证。
