Advanced Processing Technology Research Centre, School of Mechanical and Manufacturing Engineering, Dublin City University , Dublin, Ireland.
Centre for Microfluidics and Medical Diagnostics, University of Notre Dame , Notre Dame, Indiana 46556, USA.
Biomicrofluidics. 2014 Oct 16;8(5):052112. doi: 10.1063/1.4898632. eCollection 2014 Sep.
The capability of 3D printing technologies for direct production of complex 3D structures in a single step has recently attracted an ever increasing interest within the field of microfluidics. Recently, ultrafast lasers have also allowed developing new methods for production of internal microfluidic channels within the bulk of glass and polymer materials by direct internal 3D laser writing. This review critically summarizes the latest advances in the production of microfluidic 3D structures by using 3D printing technologies and direct internal 3D laser writing fabrication methods. Current applications of these rapid prototyped microfluidic platforms in biology will be also discussed. These include imaging of cells and living organisms, electrochemical detection of viruses and neurotransmitters, and studies in drug transport and induced-release of adenosine triphosphate from erythrocytes.
3D 打印技术在单一步骤中直接生产复杂 3D 结构的能力最近在微流控领域引起了越来越多的兴趣。最近，超快激光也允许通过直接内部 3D 激光写入在玻璃和聚合物材料的主体内开发生产内部微流道的新方法。本综述批判性地总结了使用 3D 打印技术和直接内部 3D 激光写入制造方法生产微流控 3D 结构的最新进展。还讨论了这些快速原型微流控平台在生物学中的当前应用。这些应用包括细胞和生物活体的成像、病毒和神经递质的电化学检测，以及药物运输和从红细胞中诱导释放三磷酸腺苷的研究。
