神经和精神疾病是一种神经胶质功能衰竭。
Neurological and psychiatric disorders as a neuroglial failure.
作者信息
Verkhratsky Alexei, Parpura Vladimir
机构信息
Faculty of Life Sciences, The University of Manchester, Manchester, M13 9PT, UK ; Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain ; University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia.
Department of Neurobiology, Center for Glial Biology in Medicine, Atomic Force Microscopy & Nanotechnology Laboratories, Civitan International Research Center, Evelyn F. McKnight Brain Institute, University of Alabama, Birmingham, AL 35294, USA ; Department of Biotechnology, University or Rijeka, 51000 Rijeka, Croatia.
出版信息
Period Biol. 2014 Jul;116(2):115-124.
Abstract
Neuroglia are a diverse non-neuronal population of cells in the central and peripheral nervous system. These cells have a variety of functions that can all be summed up as the maintenance of homeostasis of the nervous system. It is the loss of homeostasis that represents the culprit of all disorders. Thus, neuroglia can be envisioned as the pivotal element in all neural disorders, be that neurological or psychiatric. In this review, we discuss the role of glia in homeostasis and defence of the nervous system as well as changes in the morpho-functional characteristics of these cells in various disorders.
摘要
神经胶质细胞是中枢神经系统和周围神经系统中一类多样的非神经元细胞群体。这些细胞具有多种功能，所有功能都可概括为维持神经系统的内稳态。内稳态的丧失是所有疾病的罪魁祸首。因此，神经胶质细胞可被视为所有神经疾病（无论是神经学疾病还是精神疾病）的关键因素。在本综述中，我们讨论了神经胶质细胞在神经系统内稳态和防御中的作用，以及这些细胞在各种疾病中的形态功能特征变化。
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