The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510180, China.
Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore 138667.
Mol Cells. 2022 Nov 30;45(11):781-788. doi: 10.14348/molcells.2022.0115. Epub 2022 Nov 2.
Proline plays a multifaceted role in protein synthesis, redox balance, cell fate regulation, brain development, and other cellular and physiological processes. Here, we focus our review on proline metabolism in neurons, highlighting the role of dysregulated proline metabolism in neuronal dysfunction and consequently neurological and psychiatric disorders. We will discuss the association between genetic and protein function of enzymes in the proline pathway and the development of neurological and psychiatric disorders. We will conclude with a potential mechanism of proline metabolism in neuronal function and mental health.
脯氨酸在蛋白质合成、氧化还原平衡、细胞命运调控、大脑发育和其他细胞及生理过程中发挥着多方面的作用。在这里，我们重点关注脯氨酸在神经元中的代谢，强调失调的脯氨酸代谢在神经元功能障碍以及随后的神经和精神疾病中的作用。我们将讨论脯氨酸途径中酶的遗传和蛋白质功能与神经和精神疾病发展之间的关系。最后，我们将提出脯氨酸代谢在神经元功能和心理健康中的潜在机制。
