Al-Duliamy Munad J, Ghaib Nidhal H, Kader Omar A, Abdullah Bashar H
College of Dentistry, AL_Iraqia University, Iraq.
Department of Orthodontics, College of Dentistry, University of Baghdad, Iraq.
Saudi Dent J. 2015 Jan;27(1):22-9. doi: 10.1016/j.sdentj.2014.08.001. Epub 2014 Oct 24.
To examine the clinical and histological effects of locally injected strontium on the anchoring unit of a rat model of an experimental relapsed tooth movement.
Thirty-six 10-week-old male Wister rats were randomly divided into two groups of 18 animals that were then randomly divided into three subgroups of six animals corresponding to three observation periods: T1 = 1 week, T2 = 2 weeks, and T3 = 3 weeks. In the first experiment, both the right and left maxillary first molars were moved buccally with a standardized expansive spring. Strontium chloride solution was injected every 2 days into the subperiosteal area buccal to the left maxillary first molar (the experimental side). The right-sided first molar was injected with distilled water as a control. In the second experiment, maxillary first molars were moved buccally with the spring. After 3 weeks, the spring was removed. Two days before the spring removal, strontium chloride was injected into the palatal side of left-sided maxillary first molar and distilled water was injected into the palatal side of the right-sided maxillary first molar as in experiment 1.
At the end of the experimental period, significant levels of inhibition were noted in terms of both tooth movement and relapse movement in strontium-injected sides. Histological examinations showed that strontium enhanced the number of osteoblasts and reduced the number of osteoclasts.
The local injection of strontium can inhibit the degree of experimental and relapsed tooth movement in a rat model.
研究局部注射锶对实验性复发性牙齿移动大鼠模型锚固单元的临床和组织学影响。
将36只10周龄雄性Wistar大鼠随机分为两组，每组18只，然后再随机分为三个亚组，每组6只，分别对应三个观察期：T1 = 1周、T2 = 2周、T3 = 3周。在第一个实验中，使用标准化的扩弓弹簧将左右上颌第一磨牙颊向移动。每隔2天向左侧上颌第一磨牙颊侧的骨膜下区域（实验侧）注射氯化锶溶液。右侧第一磨牙注射蒸馏水作为对照。在第二个实验中，用弹簧将上颌第一磨牙颊向移动。3周后取出弹簧。在取出弹簧前两天，如实验1一样，向左侧上颌第一磨牙腭侧注射氯化锶，向右侧上颌第一磨牙腭侧注射蒸馏水。
在实验期结束时，注射锶的一侧在牙齿移动和复发移动方面均出现显著的抑制水平。组织学检查显示，锶增加了成骨细胞数量，减少了破骨细胞数量。
在大鼠模型中，局部注射锶可抑制实验性和复发性牙齿移动的程度。
