Carabin Hélène, Traoré Aminata A
Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104.
Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104. Tel: 405 271-2229.
Curr Trop Med Rep. 2014 Dec 1;1(4):181-193. doi: 10.1007/s40475-014-0029-4.
was declared potentially eradicable by the International Task Force for Disease Eradication in 1992. Yet, very few well-designed community-based randomized controlled trials have been conducted to measure the effectiveness of alternative control strategies. Most strategies have been tested in pre-post intervention designs in very few communities, often without a control group. The only two community-based randomized controlled trials suggest that an educational program alone or a combination of human and porcine mass treatment reduce porcine cysticercosis in the short term. A transmission dynamics model suggests that improved sanitation and pig management are more effective and sustainable than pig vaccination, human or porcine mass treatment. Current evidence does not support the eradication of in the foreseeable future. Investigators should follow international recommendations on the conduct of community-based randomized control trials to provide more valid estimates of the effect and cost-effectiveness of alternative control strategies for cysticercosis.
1992年，国际疾病根除特别工作组宣布该病有可能被根除。然而，很少有精心设计的基于社区的随机对照试验来衡量替代控制策略的有效性。大多数策略仅在极少数社区的干预前后设计中进行了测试，而且往往没有对照组。仅有的两项基于社区的随机对照试验表明，单独的教育项目或人和猪的群体治疗相结合在短期内可减少猪囊尾蚴病。一个传播动力学模型表明，改善卫生条件和猪的管理比猪疫苗接种、人和猪的群体治疗更有效且可持续。目前的证据不支持在可预见的未来根除该病。研究人员应遵循关于开展基于社区的随机对照试验的国际建议，以便更有效地估计囊尾蚴病替代控制策略的效果和成本效益。
