用重组六钩蚴抗原疫苗对自然饲养的猪成功进行猪囊尾蚴病免疫接种。
Successful immunization of naturally reared pigs against porcine cysticercosis with a recombinant oncosphere antigen vaccine.
作者信息
Jayashi César M, Kyngdon Craig T, Gauci Charles G, Gonzalez Armando E, Lightowlers Marshall W
机构信息
Veterinary Clinical Centre, The University of Melbourne, 250 Princes Hwy, Werribee, Victoria 3030, Australia.
出版信息
Vet Parasitol. 2012 Sep 10;188(3-4):261-7. doi: 10.1016/j.vetpar.2012.03.055. Epub 2012 Apr 4.
Abstract
Taenia solium causes cysticercosis in pigs and taeniasis and neurocysticercosis in humans. Oncosphere antigens have proven to be effective as vaccines to protect pigs against an experimental infection with T. solium. A pair-matched vaccination trial field, using a combination of two recombinant antigens, TSOL16 and TSOL18, was undertaken in rural villages of Peru to evaluate the efficacy of this vaccine under natural conditions. Pairs of pigs (n=137) comprising one vaccinated and one control animal, were allocated to local villagers. Animals received two vaccinations with 200 μg of each of TSOL16 and TSOL18, plus 5mg Quil-A. Necropsies were performed 7 months after the animals were distributed to the farmers. Vaccination reduced 99.7% and 99.9% (p<0.01) the total number of cysts and the number of viable cysts, respectively. Immunization with the TSOL16-TSOL18 vaccines has the potential to control T. solium transmission in areas where the disease is endemic, reducing the source for tapeworm infections in humans.
摘要
猪带绦虫可导致猪患囊尾蚴病，以及人类患绦虫病和神经囊尾蚴病。六钩蚴抗原已被证明作为疫苗可有效保护猪免受猪带绦虫的实验性感染。在秘鲁的农村村庄开展了一项配对疫苗接种试验，使用两种重组抗原TSOL16和TSOL18的组合，以评估该疫苗在自然条件下的效力。将成对的猪（n = 137）（每对包括一头接种疫苗的猪和一头对照猪）分配给当地村民。动物接受两次疫苗接种，每次接种200μg的TSOL16和TSOL18，外加5mg Quil-A。在将动物分发给农民7个月后进行尸检。接种疫苗分别使囊肿总数和活囊肿数量减少了99.7%和99.9%（p<0.01）。用TSOL16 - TSOL18疫苗进行免疫接种有可能在该病流行地区控制猪带绦虫的传播，减少人类绦虫感染的来源。
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