Aschengrau A, Zierler S, Cohen A
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
Arch Environ Health. 1989 Sep-Oct;44(5):283-90. doi: 10.1080/00039896.1989.9935895.
To investigate the relationship between community drinking water quality and spontaneous abortion, we compared trace element levels in the drinking water of 286 women having a spontaneous abortion through 27 wk gestation with that of 1,391 women having livebirths. Trace element levels were gathered from routine analyses of public tap water supplies from the communities where the women resided during pregnancy. After adjustment for potential confounders, an increase in the frequency of spontaneous abortion was associated with detectable levels of mercury; high levels of arsenic, potassium, and silica; moderately hard water, and surface water. In contrast, a decrease in the frequency of spontaneous abortion was associated with high levels of alkalinity and sulfate, and any detectable level of nitrate. These results require further corroboration because there is a paucity of data investigating this issue.
为了研究社区饮用水质量与自然流产之间的关系，我们比较了286名妊娠27周内自然流产妇女与1391名分娩活产妇女的饮用水中微量元素水平。微量元素水平来自对这些妇女孕期居住社区公共自来水供应的常规分析。在对潜在混杂因素进行调整后，自然流产频率的增加与可检测到的汞水平、高浓度的砷、钾和硅、中度硬水以及地表水有关。相比之下，自然流产频率的降低与高浓度的碱度和硫酸盐以及任何可检测到的硝酸盐水平有关。由于研究该问题的数据较少，这些结果需要进一步证实。
