MMWR Morb Mortal Wkly Rep. 1996 Jul 5;45(26):569-72.
Health effects associated with ingestion of nitrate-contaminated water have included methemoglobinemia (i.e., blue baby syndrome) in infants and spontaneous abortions in laboratory animals and livestock; however, only one study in humans has reported an association between increased methemoglobin levels and spontaneous abortion. During March 1993, the LaGrange County (Indiana) Health Department (LCHD) identified three women who reported a total of six spontaneous abortions during 1991-1993 and who resided in proximity to each other; each had obtained drinking water from nitrate-contaminated private wells in LaGrange County (1995 population: 29,350). LCHD was subsequently notified about a fourth woman from another part of the county who had had two spontaneous abortions after she had moved into a new home with a nitrate-contaminated private well. This report summarizes the investigations of these reports by LCHD, which indicate the need for further assessment of a possible relation between ingesting nitrate-contaminated water and spontaneous abortion.
摄入受硝酸盐污染的水对健康的影响包括婴儿高铁血红蛋白血症（即蓝婴综合征）以及实验动物和家畜的自然流产；然而，仅有一项针对人类的研究报告了高铁血红蛋白水平升高与自然流产之间的关联。1993年3月，拉格朗日县（印第安纳州）卫生局（LCHD）确认了三名女性，她们报告在1991年至1993年期间总共发生了六次自然流产，且居住在彼此附近；她们均从拉格朗日县受硝酸盐污染的私人水井中获取饮用水（1995年人口：29,350）。随后，LCHD接到通知，该县另一地区的第四名女性在搬进一所带有受硝酸盐污染的私人水井的新家后，发生了两次自然流产。本报告总结了LCHD对这些报告的调查情况，调查表明需要进一步评估摄入受硝酸盐污染的水与自然流产之间可能存在的关系。
