Wang Lele, Yang Xue, Shen Yuequan
State Key Laboratory of Medicinal Chemical Biology, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
Cell Mol Life Sci. 2015 Apr;72(8):1489-98. doi: 10.1007/s00018-014-1810-1. Epub 2014 Dec 30.
Mitochondrial calcium uptake plays a critical role in various cellular functions. After half a century of extensive studies, the molecular components and important regulators of the mitochondrial calcium uptake complex have been identified. However, the mechanism by which these protein molecules interact with one another and coordinate to regulate calcium passage through mitochondrial membranes remains elusive. Here, we summarize recent progress in the structural and functional characterization of these important protein molecules, which are involved in mitochondrial calcium uptake. In particular, we focus on the current understanding of the molecular mechanism underlying calcium through two mitochondrial membranes. Additionally, we provide a new perspective for future directions in investigation and molecular intervention.
线粒体钙摄取在各种细胞功能中起着关键作用。经过半个世纪的广泛研究，已确定了线粒体钙摄取复合体的分子成分和重要调节因子。然而，这些蛋白质分子相互作用并协同调节钙通过线粒体膜的机制仍不清楚。在这里，我们总结了这些参与线粒体钙摄取的重要蛋白质分子在结构和功能表征方面的最新进展。特别是，我们重点关注目前对钙通过两层线粒体膜的分子机制的理解。此外，我们为未来的研究方向和分子干预提供了新的视角。
