Lim Hyoung-Ji, Seo Min-Seok, Shim Jae-Yong, Kim Kyu-Earn, Shin Youn Ho, Lee Yong-Jae
a Department of Family Medicine , Gangnam Severance Hospital, Yonsei University College of Medicine , Seoul , Korea .
b Department of Medicine , Yonsei University Graduate School of Medicine , Seoul , Korea .
Platelets. 2015;26(8):758-63. doi: 10.3109/09537104.2014.995613. Epub 2014 Dec 30.
The goal of this study was to evaluate the association between platelet count and metabolic syndrome (MetS) in children and adolescents in Korea. This study included data from 2228 subjects (1201 boys and 1027 girls) who participated in the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES-V). We used the modified National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria to define MetS. Odds ratios (95% confidence intervals [CIs]) for MetS were calculated with a multiple logistic regression analysis after adjusting for confounding factors across platelet count quartiles. The overall prevalence of MetS according to the modified NCEP-ATP III criteria was 4.9% (± 0.7%) in boys and 5.7% (± 0.9%) in girls. The prevalence of MetS significantly increased with increasing platelet quartiles in both boys and girls. In a multiple logistic regression analysis, the adjusted ORs (95% CIs) for the highest vs. the lowest quartile were 5.03 (1.30-19.48) in boys and 4.08 (1.20-13.93) in girls after adjusting for age and total cholesterol.
Higher platelet count was associated with increased prevalence and risk of MetS in children and adolescents.
本研究的目的是评估韩国儿童和青少年血小板计数与代谢综合征（MetS）之间的关联。本研究纳入了2010 - 2012年韩国国家健康与营养检查调查（KNHANES - V）中2228名受试者（1201名男孩和1027名女孩）的数据。我们采用修改后的美国国家胆固醇教育计划成人治疗组第三次报告（NCEP - ATP III）标准来定义代谢综合征。在对血小板计数四分位数的混杂因素进行调整后，通过多因素逻辑回归分析计算代谢综合征的比值比（95%置信区间[CIs]）。根据修改后的NCEP - ATP III标准，男孩中代谢综合征的总体患病率为4.9%（±0.7%），女孩为5.7%（±0.9%）。男孩和女孩中，代谢综合征的患病率均随血小板四分位数的增加而显著升高。在多因素逻辑回归分析中，在调整年龄和总胆固醇后，最高四分位数与最低四分位数相比，男孩的调整后比值比（95% CIs）为5.03（1.30 - 19.48），女孩为4.08（1.20 - 13.93）。
较高的血小板计数与儿童和青少年代谢综合征患病率及风险增加相关。
