Szymaniec S, Brown D M, Chladzynska M, Jankowska E, Polikowska H, Donaldson K
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw.
Br J Ind Med. 1989 Oct;46(10):724-8. doi: 10.1136/oem.46.10.724.
Experiments were carried out to assess the effect of intraperitoneal injection of the mineral dusts, titanium dioxide, quartz, or asbestos, on splenic lymphocyte antibody forming cells in immunised mice. Titanium dioxide and quartz caused similar, about one third, reductions in plaque forming cells; asbestos caused substantial reduction to about a quarter of the number found in control spleens. The inhibition of antibody forming cells in the spleen found with chrysotile was dose dependent and both chrysotile and crocidolite asbestos were similar in activity. Systemic immunomodulation after local deposition of mineral dust may be important to the development of disease.
进行了实验以评估腹腔注射矿物粉尘（二氧化钛、石英或石棉）对免疫小鼠脾脏淋巴细胞抗体形成细胞的影响。二氧化钛和石英导致类似的约三分之一的噬斑形成细胞减少；石棉导致大幅减少至对照脾脏中发现数量的约四分之一。温石棉导致的脾脏中抗体形成细胞的抑制呈剂量依赖性，温石棉和青石棉在活性方面相似。矿物粉尘局部沉积后的全身免疫调节可能对疾病的发展很重要。
