Gormley I P, Kowolik M J, Cullen R T
Br J Exp Pathol. 1985 Aug;66(4):409-16.
Luminol-dependent chemiluminescence (CL) was used to assess the in vitro production of reactive oxygen species by human neutrophils and monocytes on exposure to six standard respirable mineral dusts. Every dust caused CL production in both phagocytic cell types, although, for each dust, the two cells showed a different pattern of response. Light output was markedly affected by the presence of serum in the system. While the results illustrated the complexity of the interaction between mineral dusts and monocytes and neutrophils, they did not support the hypothesis that pathogenic dusts would induce the production of more reactive oxygen species than non-pathogenic dusts.
采用鲁米诺依赖化学发光法（CL）评估人类中性粒细胞和单核细胞在暴露于六种标准可吸入矿物粉尘时活性氧的体外产生情况。每种粉尘均能使两种吞噬细胞类型产生CL，不过，对于每种粉尘，两种细胞呈现出不同的反应模式。系统中血清的存在对光输出有显著影响。虽然结果表明矿物粉尘与单核细胞和中性粒细胞之间相互作用的复杂性，但并不支持致病性粉尘比非致病性粉尘诱导产生更多活性氧的假说。
