CD24表达预示皮肤恶性黑色素瘤患者预后不良。
CD24 expression predicts poor prognosis for patients with cutaneous malignant melanoma.
作者信息
Tang Ming-Rui, Wang Yu-Xin, Guo Shu, Han Si-Yuan, Li He-Huan, Jin Shi-Feng
机构信息
Department of Plastic Surgery, The First Hospital of China Medical University 155 Nanjing North Street, Heping District, Shenyang City 110001, Liaoning Province, China.
出版信息
Int J Clin Exp Med. 2014 Nov 15;7(11):4337-41. eCollection 2014.
Abstract
Cutaneous malignant melanoma represents the major cause of mortality among skin cancers. Metastasis-associated protein CD24 is a small, heavily glycosylated cell surface protein that is overexpressed in various human malignancies. The present study was designed to determine the roles of CD24 in cutaneous malignant melanoma. The levels of CD24 mRNA and protein in cutaneous malignant melanoma tissues were detected by RT-PCR, Western blot and IHC. In patient samples, the levels of CD24 mRNA and protein were higher in cancer tissues than that in normal tissues. CD24 expression decreased the survival time of the patients with melanoma. Taken together, these results suggest that CD24 may be used as a new drug target for cutaneous malignant melanoma.
摘要
皮肤恶性黑色素瘤是皮肤癌致死的主要原因。转移相关蛋白CD24是一种小型、高度糖基化的细胞表面蛋白，在多种人类恶性肿瘤中过表达。本研究旨在确定CD24在皮肤恶性黑色素瘤中的作用。通过逆转录聚合酶链反应（RT-PCR）、蛋白质免疫印迹法（Western blot）和免疫组织化学（IHC）检测皮肤恶性黑色素瘤组织中CD24 mRNA和蛋白的水平。在患者样本中，癌组织中CD24 mRNA和蛋白的水平高于正常组织。CD24表达缩短了黑色素瘤患者的生存时间。综上所述，这些结果表明CD24可能作为皮肤恶性黑色素瘤的新药物靶点。
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