表皮生长因子乳膏对 Q 开关 532nm 掺钕钇铝石榴石激光治疗后炎症后色素沉着的影响。
Effect of an epidermal growth factor-containing cream on postinflammatory hyperpigmentation after Q-switched 532-nm neodymium-doped yttrium aluminum garnet laser treatment.
机构信息
*Department of Dermatology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea; †Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
出版信息
Dermatol Surg. 2015 Jan;41(1):131-5. doi: 10.1097/DSS.0000000000000197.
BACKGROUND
Topical application of epidermal growth factor (EGF) promotes wound healing and may reduce the risk of laser-induced postinflammatory hyperpigmentation (PIH).
OBJECTIVE
To investigate the effect of an EGF-containing cream on the incidence of laser-induced PIH.
METHODS
Twenty-five Korean patients with senile lentigines were recruited and underwent 532-nm Q-switched Nd:YAG laser treatment. Postoperatively, patients applied either an EGF-containing cream or a control cream to the laser-treated area. Skin color and transepidermal water loss (TEWL) were measured on Days 0, 3, 7, and 35 using a Mexameter and Tewameter, respectively.
RESULTS
The EGF-containing cream resulted in a nonsignificant reduction in the laser-induced increase in TEWL (p = .052 on Day 7) but significantly decreased the melanin index and incidence of PIH on Day 35 (p = .031 and p = .027, respectively).
CONCLUSION
Epidermal growth factor-containing creams may be an effective measure to prevent laser treatment-induced PIH in Asian patients.
背景
表皮生长因子（EGF）的局部应用可促进伤口愈合，并可能降低激光诱导的炎症后色素沉着过度（PIH）的风险。
目的
研究含 EGF 的乳膏对激光诱导 PIH 发生率的影响。
方法
招募了 25 名患有老年斑的韩国患者，并对其进行了 532nm Q 开关 Nd:YAG 激光治疗。术后，患者将含 EGF 的乳膏或对照乳膏涂抹于激光治疗区域。分别于第 0、3、7 和 35 天使用 Mexameter 和 Tewameter 测量皮肤颜色和经表皮水分流失（TEWL）。
结果
含 EGF 的乳膏对激光诱导的 TEWL 增加没有显著降低（第 7 天 p =.052），但在第 35 天显著降低了黑色素指数和 PIH 的发生率（p =.031 和 p =.027）。
结论
含 EGF 的乳膏可能是预防亚洲患者激光治疗后 PIH 的有效措施。
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