运动训练对去卵巢肥胖大鼠棕色脂肪组织产热的影响。

Effects of exercise training on brown adipose tissue thermogenesis in ovariectomized obese rats.

作者信息

Yoshioka K, Yoshida T, Wakabayashi Y, Nishioka H, Kondo M

机构信息

First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.

出版信息

Endocrinol Jpn. 1989 Jun;36(3):403-8. doi: 10.1507/endocrj1954.36.403.

DOI:10.1507/endocrj1954.36.403

PMID:2555143

Abstract

The effect of exercise training on brown adipose tissue (BAT) thermogenesis was studied by measuring cytochrome oxidase activity, as a marker of mitochondrial abundance, mitochondrial guanosine-5'-diphosphate (GDP) binding, as an indicator of thermogenic activity and oxygen consumption in BAT in ovariectomized (OVX) obese rats and sham-operated rats. Six-week exercise training significantly suppressed body weight gain in OVX rats to the level of sedentary control rats, although food intake in exercise trained OVX rats increased more than in the sedentary OVX rats. Exercise training increased cytochrome oxidase activity, mitochondrial GDP binding and oxygen consumption in BAT in OVX rats, which were reduced in a sedentary condition, as well as in the control rats. These results suggest that exercise training potentiates BAT thermogenesis, which may contribute to the reduction of body weight in OVX obese rats.

摘要

通过测量细胞色素氧化酶活性（作为线粒体丰度的标志物）、线粒体鸟苷 - 5'-二磷酸（GDP）结合（作为产热活性的指标）以及去卵巢（OVX）肥胖大鼠和假手术大鼠棕色脂肪组织（BAT）中的耗氧量，研究了运动训练对棕色脂肪组织产热的影响。六周的运动训练显著抑制了OVX大鼠的体重增加，使其降至久坐对照大鼠的水平，尽管运动训练的OVX大鼠的食物摄入量比久坐的OVX大鼠增加得更多。运动训练增加了OVX大鼠BAT中的细胞色素氧化酶活性、线粒体GDP结合和耗氧量，这些在久坐状态下以及对照大鼠中均有所降低。这些结果表明，运动训练增强了BAT产热，这可能有助于减轻OVX肥胖大鼠的体重。