BACKGROUND/AIM: The study aims to systematically analyze the body of literature concerning the effects of colchicine on the cardiovascular system, providing a comprehensive evaluation of the current knowledge and highlighting the clinical and scientific relevance of colchicine in this field. MATERIALS AND METHODS: Data were obtained from the Web of Science (WOS), Scopus, and PubMed databases on March 17, 2025. The search terms included "Colchicine" AND ("Cardiovascular Diseases" OR "Heart Diseases" OR "Coronary Artery Disease" OR "Myocarditis" OR "Pericarditis" OR "Atherosclerosis" OR "Heart Failure" OR "Myocardial Infarction" OR "Ischemic Heart Disease" OR "Acute Coronary Syndrome" OR "Cardiac Arrhythmias" OR "Thrombosis" OR "Stroke"). No restrictions were applied regarding publication date or language, ensuring the comprehensive retrieval of relevant data. Publications were categorized according to their document type and indexes. Additionally, a cooccurrence analysis of key words was conducted using VOSviewer 1.6.18. RESULTS: A total of 425 publications on the effects of colchicine on the cardiovascular system were identified, published between 1976 and 2025. There has been a significant increase in research since 2015. Most publications were in the Cardiac Cardiovascular Systems category. "Colchicine" was the most frequently used key word, appearing 170 times. The USA ranked first in publication count, with 163 studies. The USA, Italy, Canada, and China played significant roles in global research collaboration. CONCLUSION: This bibliometric analysis demonstrates the increasing importance of colchicine as a therapeutic agent in the management of cardiovascular disease.