Reichart P A, Langford A, Gelderblom H R, Pohle H D, Becker J, Wolf H
Abteilung für zahnärztliche Chirurgie/Oralchirurgie-Nord-Freie Universität Berlin, West Germany.
J Oral Pathol Med. 1989 Aug;18(7):410-5. doi: 10.1111/j.1600-0714.1989.tb01573.x.
Oral hairy leukoplakia (HL) was observed in 25.4% of 373 HIV-seropositive patients (n = 95). 87 were men of an average age of 37.1 yr, 8 were women (30.3 yr). 71.6% of the patients were male homosexuals. At initial diagnosis of HL the majority of cases was classified as CDC IVc1 (45.3%) and CDC II (22.1%). Average CD4/CD8 ratio (n = 19) was 0.24 with a range of 0.04-1.0. Thirty biopsies of HL revealed some of the histologic features thought to be characteristic. In only 20 of 30 biopsies EB-virus-specific-capsid antigen was detected. The problems of clinical and histological diagnosis of HL are discussed. Further strict criteria are necessary in order to define HL more distinctly.
在373例HIV血清反应阳性患者（n = 95）中，观察到25.4%的患者患有口腔毛状白斑（HL）。其中87例为男性，平均年龄37.1岁，8例为女性（30.3岁）。71.6%的患者为男性同性恋者。在HL初诊时，大多数病例被归类为疾病控制中心（CDC）IVc1（45.3%）和CDC II（22.1%）。平均CD4/CD8比值（n = 19）为0.24，范围为0.04 - 1.0。对30例HL进行活检，发现了一些被认为具有特征性的组织学特征。在30例活检中，仅20例检测到EB病毒特异性衣壳抗原。文中讨论了HL的临床和组织学诊断问题。为了更明确地定义HL，需要进一步严格的标准。
