Syrjänen S, Laine P, Niemelä M, Happonen R P
Department of Oral Pathology, University of Kuopio, Finland.
J Oral Pathol Med. 1989 Jan;18(1):28-31. doi: 10.1111/j.1600-0714.1989.tb00728.x.
Oral hairy leukoplakia (HL) has been regarded as an early sign of HIV infection, and its clinical importance related to the poor outcome of the patients has been emphasized. Initially, HL was observed exclusively among male homosexuals, but subsequently demonstrated in all risk groups of HIV infection. The patient described in this article suggests that oral HL is not specific for HIV infection per se, but may be associated with immunosuppression also due to other causes. We describe an HIV-seronegative, heterosexual man suffering from an acute myeloblastic leukemia, who developed clinically and histologically typical HL while on cytostatics. Biopsy showed areas with characteristic ballooning cells, and hyphae of yeasts were demonstrated with PAS-stain. Using the in situ hybridization technique, Epstein-Barr virus (EBV) DNA with high copy numbers was disclosed in the superficial and intermediate cells, whereas human papillomavirus (HPV) DNA (types 6, 11, 16, 18) was not present.
口腔毛状白斑（HL）一直被视为人类免疫缺陷病毒（HIV）感染的早期迹象，其与患者不良预后相关的临床重要性已得到强调。最初，HL仅在男性同性恋者中观察到，但随后在所有HIV感染风险组中均有发现。本文所述患者表明，口腔HL本身并非HIV感染所特有，但也可能与其他原因导致的免疫抑制有关。我们描述了一名HIV血清阴性的异性恋男性，他患有急性髓细胞白血病，在接受细胞抑制剂治疗期间出现了临床和组织学上典型的HL。活检显示有特征性气球样细胞区域，过碘酸雪夫（PAS）染色显示有酵母菌丝。采用原位杂交技术，在表层和中层细胞中发现了高拷贝数的爱泼斯坦-巴尔病毒（EBV）DNA，而人乳头瘤病毒（HPV）DNA（6、11、16、18型）未检出。
