Wang Zhuo, Lin Zhong-Wei, Huang Lei-Lei, Ke Zun-Fu, Luo Can-Jiao, Xie Wen-Lin, Wang Lian-Tang
Department of Pathology, The First Affiliated Hospital of Sun Yat-Sen University Guangzhou, China.
Department of Cardiology, The First Affiliated Hospital of Guangdong Pharmaceputical University Guangzhou, China.
Int J Clin Exp Med. 2014 Nov 15;7(11):4503-8. eCollection 2014.
Primary xanthoma of bone is very rare. And its clinical, pathological and radiological presentation is different from other position. It is generally known that xanthoma of bone are usually are associated with lipid disorders. Non-hyperlipidemia xanthoma of bone are exceedingly unusual. In this report, we describe a rare case of primary bone xanthoma without hyperlipidemia and reviews the literature on primary bone xanthomas, focusing on those without hyperlipidemia. The difference of age between non-hyperlipidemia xanthoma of bone and other xanthoma of bone did not existed. But male patients outnumber female in non-hyperlipidemia xanthoma of bone. It often involve the irregular flat bones than the long bones. Inflammatory cells, cholesterol clefts and hemosiderin are rare compared with xanthoma with lipid disorders. At the same time, imaging manifestations is not steady, except for osteolytic sign. So the diagnosis usually depend on a pathological biopsy. Therefore we suggested that non-hyperlipidemia xanthoma of bone was a kind of independent disease. It should be belong to bone tumors of undefined neoplastic nature. Its etiology need more data collection and further analysis.
原发性骨黄瘤非常罕见。其临床、病理及影像学表现与其他部位不同。一般认为骨黄瘤通常与脂质紊乱有关。非高脂血症性骨黄瘤极为罕见。在本报告中，我们描述了一例无高脂血症的原发性骨黄瘤罕见病例，并回顾了原发性骨黄瘤的相关文献，重点关注无高脂血症的病例。非高脂血症性骨黄瘤与其他骨黄瘤在年龄上不存在差异。但在非高脂血症性骨黄瘤中男性患者多于女性。它常累及不规则扁骨而非长骨。与伴有脂质紊乱的黄瘤相比，炎性细胞、胆固醇裂隙和含铁血黄素较少见。同时，除溶骨征象外，影像学表现不稳定。因此诊断通常依赖病理活检。所以我们认为非高脂血症性骨黄瘤是一种独立的疾病。它应属于肿瘤性质未明的骨肿瘤。其病因需要更多的数据收集和进一步分析。
