Michaels Margo, Blakeney Natasha, Langford Aisha T, Ford Marvella E
Education Network to Advance Cancer Clinical Trials, 7625 Wisconsin Avenue, Suite 300, Bethesda, MD, 20814, USA,
J Cancer Educ. 2015 Mar;30(1):197-203. doi: 10.1007/s13187-014-0699-6.
Participation in cancer clinical trials (CCTs) is a key measure for delivery of quality cancer care. Yet, adult cancer patient participation in CCTs remains at about 3%, and participation rates are even lower among ethnic and racial minorities and the medically underserved. Social justice demands better representation of all populations in CCTs to ensure equal access to clinical trials and to ensure greater generalizability of trial results. Using a conceptual framework, this paper outlines a set of guiding principles deemed essential for effective and ethical implementation of community-based education in CCTs. Also described are examples of interventions related to this framework that have been used to overcome key barriers to trial enrollment among underserved populations. Application of the key principles, combined with ongoing engagement of cancer care institutions, suggests promise in enhancing trial participation.
参与癌症临床试验（CCTs）是提供优质癌症护理的一项关键措施。然而，成年癌症患者参与CCTs的比例仍约为3%，在少数族裔和医疗服务不足人群中参与率甚至更低。社会正义要求所有人群在CCTs中得到更好的代表，以确保平等参与临床试验并确保试验结果具有更高的普遍性。本文使用一个概念框架，概述了一套对于在CCTs中有效且符合伦理地开展社区教育至关重要的指导原则。还介绍了与该框架相关的干预措施示例，这些措施已被用于克服服务不足人群参与试验的关键障碍。关键原则的应用，再加上癌症护理机构的持续参与，有望提高试验参与率。
