Lima Leandra G, Bonardi José M T, Campos Giulliard O, Bertani Rodrigo F, Scher Luria M L, Louzada-Junior Paulo, Moriguti Júlio C, Ferriolli Eduardo, Lima Nereida K C
Division of General Internal Medicine and Geriatrics, School of Medicine of Ribeirão Preto, University of São Paulo-FMRP-USP, São Paulo, Brazil.
Aging Clin Exp Res. 2015 Aug;27(4):483-9. doi: 10.1007/s40520-014-0307-y. Epub 2015 Jan 8.
There is a relationship between high levels of inflammatory markers and low adhesion to the practice of physical activity in the older population. The objective of the present study was to compare the effect of two types of exercise programs, i.e., aerobic training and aerobic plus resistance training on the plasma levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) of elderly hypertensive subjects. Hypertensive older volunteers in use of antihypertensive drugs were randomized to three groups: aerobic group (AG), resistance and aerobic group (RAG) and control group (CG). Training lasted 10 weeks, with sessions held three times a week. Blood samples were collected before training and 24 h after completion of the 30 sessions for the determination of serum IL-6 and TNF-α levels. Body mass index was obtained before and after 10 weeks. After intervention, BMI values were lower in AG and RAG compared to CG (p < 0.001), IL-6 was reduced in AG compared to CG (p = 0.04), and TNF-α levels were lower only in RAG compared to CG (p = 0.01). Concluding, both types of training were effective in reducing BMI values in hypertensive older subjects. Aerobic exercise produced the reduction of plasma IL-6 levels. However, the combination of aerobic and resistance exercise, which would be more indicated for the prevention of loss of functionality with aging, showed lower TNF-α mediator after training than control group and a greater fall of TNF-α levels associated to higher BMI reduction.
在老年人群中，炎症标志物水平升高与体育活动依从性低之间存在关联。本研究的目的是比较两种运动方案，即有氧运动训练和有氧加抗阻训练，对老年高血压患者血浆白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平的影响。正在使用抗高血压药物的老年高血压志愿者被随机分为三组：有氧运动组（AG）、抗阻和有氧运动组（RAG）和对照组（CG）。训练持续10周，每周进行三次。在训练前和完成30次训练后24小时采集血样，以测定血清IL-6和TNF-α水平。在10周前后测量体重指数。干预后，AG组和RAG组的BMI值低于CG组（p<0.001），AG组的IL-6水平低于CG组（p=0.04），只有RAG组的TNF-α水平低于CG组（p=0.01）。总之，两种训练方式均能有效降低老年高血压患者的BMI值。有氧运动可降低血浆IL-6水平。然而，有氧和抗阻运动相结合，更适合预防因衰老导致的功能丧失，训练后其TNF-α介质水平低于对照组，且TNF-α水平下降幅度更大，同时BMI降低幅度更大。
