El Tahlawi Mohammad, Abdelbaset Mohammad, Gouda Mohammad, Hussein Ikhlas
Cardiology Department, Zagazig University, Zagazig, Egypt.
Hypertens Res. 2015 Apr;38(4):260-3. doi: 10.1038/hr.2014.170. Epub 2015 Jan 8.
The roles of arterial function and structure in cardiovascular physiology have expanded with the development of a variety of parameters that evaluate arterial stiffness. Markers of arterial stiffness have been correlated with cardiovascular outcomes. We aimed to find a simple, clinical, noninvasive method to predict atherosclerosis that leads to the development of coronary artery disease (CAD). We aimed to find a simple, clinical, noninvasive method to predict atherosclerosis that leads to the development of CAD. We included 100 cases that underwent coronary angiography in our center owing to different indications. The blood pressure in all cases was measured by two different observers. The oscillatory systolic blood pressure (OSBP) was defined as the point at which the mercury began to oscillate to a minimum level of 1 mm Hg. The auscultatory systolic blood pressure (AUSBP) was defined as the first Korotkoff sound. The difference between OSBP and AUSBP was calculated and called the oscillatory gap (OG). The correlation between the OG and the presence of coronary lesion in coronary angiography was statistically calculated. The study populations had a mean age of 57.3±9 years. The mean±s.d. OG was 14.44±10.44. There was a highly significantly positive correlation between the OG and the presence of coronary artery lesions (r=0.399 and P-value <0.000). There was also a significantly positive correlation between the presence of hypertension and the OG (r=0.376 and P-value <0.000). The difference between OSBP and AUSBP could be used as a simple method to detect atherosclerotic arterial changes. This method could indicate the degree of arterial stiffness. There was a significantly positive correlation between this new indicator of arterial stiffness and the presence of CAD. Any patient with a wide gap between OSBP and AUSBP should be treated early with antihypertensive drugs and statins before the development of CAD.
随着评估动脉僵硬度的各种参数的发展，动脉功能和结构在心血管生理学中的作用不断扩展。动脉僵硬度标志物已与心血管结局相关联。我们旨在找到一种简单、临床、无创的方法来预测导致冠状动脉疾病（CAD）发生的动脉粥样硬化。我们纳入了100例因不同指征在本中心接受冠状动脉造影的病例。所有病例的血压由两名不同的观察者测量。振荡收缩压（OSBP）定义为汞柱开始振荡至最低水平1毫米汞柱时的点。听诊收缩压（AUSBP）定义为第一声柯氏音。计算OSBP与AUSBP之间的差值并称为振荡间隙（OG）。对OG与冠状动脉造影中冠状动脉病变的存在之间的相关性进行了统计学计算。研究人群的平均年龄为57.3±9岁。平均±标准差的OG为14.44±10.44。OG与冠状动脉病变的存在之间存在高度显著的正相关（r = 0.399，P值<0.000）。高血压的存在与OG之间也存在显著正相关（r = 0.376，P值<0.000）。OSBP与AUSBP之间的差值可作为检测动脉粥样硬化性动脉变化的简单方法。该方法可指示动脉僵硬度的程度。这种新的动脉僵硬度指标与CAD的存在之间存在显著正相关。任何OSBP与AUSBP之间差距较大的患者都应在CAD发生之前尽早用抗高血压药物和他汀类药物进行治疗。
