• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

NOTA: a potent metallo-β-lactamase inhibitor.

作者信息

Somboro Anou M, Tiwari Dileep, Bester Linda A, Parboosing Raveen, Chonco Louis, Kruger Hendrick G, Arvidsson Per I, Govender Thavendran, Naicker Tricia, Essack Sabiha Y

机构信息

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa Antimicrobial Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

出版信息

J Antimicrob Chemother. 2015 May;70(5):1594-6. doi: 10.1093/jac/dku538. Epub 2015 Jan 6.

DOI:10.1093/jac/dku538
PMID:25567963
Abstract
摘要

相似文献

1
NOTA: a potent metallo-β-lactamase inhibitor.注意：一种强效金属β-内酰胺酶抑制剂。
J Antimicrob Chemother. 2015 May;70(5):1594-6. doi: 10.1093/jac/dku538. Epub 2015 Jan 6.
2
NOTA analogue: A first dithiocarbamate inhibitor of metallo-β-lactamases.NOTA类似物：金属β-内酰胺酶的首个二硫代氨基甲酸盐抑制剂。
Bioorg Med Chem Lett. 2018 Jan 15;28(2):214-221. doi: 10.1016/j.bmcl.2017.10.074. Epub 2017 Nov 7.
3
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors.靶向临床相关金属β-内酰胺酶：从高通量对接至广谱抑制剂
J Enzyme Inhib Med Chem. 2016;31(sup1):98-109. doi: 10.3109/14756366.2016.1172575. Epub 2016 Apr 28.
4
Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria.含有硫醇作为金属β-内酰胺酶抑制剂的获批药物：对抗多重耐药细菌的策略
J Med Chem. 2015 Apr 23;58(8):3626-30. doi: 10.1021/jm501844d. Epub 2015 Apr 13.
5
Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner.阿魏酸玛索菌素 A 通过同时抑制金属β-内酰胺酶靶位和抗生素伙伴来抑制β-内酰胺耐药性。
Antimicrob Agents Chemother. 2020 Mar 24;64(4). doi: 10.1128/AAC.01386-19.
6
Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases.具有抗抗生素耐药性金属β-内酰胺酶抑制作用的三唑抑制剂的结构研究。
Bioorg Med Chem. 2020 Aug 1;28(15):115598. doi: 10.1016/j.bmc.2020.115598. Epub 2020 Jun 18.
7
Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.一种对A类丝氨酸碳青霉烯酶有效的环状硼酸β-内酰胺酶抑制剂（RPX7009）的发现。
J Med Chem. 2015 May 14;58(9):3682-92. doi: 10.1021/acs.jmedchem.5b00127. Epub 2015 Mar 17.
8
Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers.卡托普利立体异构体对金属β-内酰胺酶抑制作用的结构基础。
Antimicrob Agents Chemother. 2015 Oct 19;60(1):142-50. doi: 10.1128/AAC.01335-15. Print 2016 Jan.
9
Progress toward inhibitors of metallo-β-lactamases.金属β-内酰胺酶抑制剂的研究进展。
Future Med Chem. 2017 May;9(7):673-691. doi: 10.4155/fmc-2017-0007. Epub 2017 May 15.
10
The times they are a-changin': carbapenems for extended-spectrum-β-lactamase-producing bacteria.时代在变：碳青霉烯类药物用于产超广谱β-内酰胺酶细菌
Antimicrob Agents Chemother. 2015 Sep;59(9):5095-6. doi: 10.1128/AAC.01333-15. Epub 2015 Jun 22.

引用本文的文献

1
Development and evaluation of 1,4,7-triazacyclononane-coupled β-lactams against metallo-β-lactamase producing bacteria.针对产金属β-内酰胺酶细菌的1,4,7-三氮杂环壬烷偶联β-内酰胺的研发与评估
RSC Adv. 2025 Jul 7;15(29):23427-23440. doi: 10.1039/d5ra01842k. eCollection 2025 Jul 4.
2
Harder than Metal: Challenging Antimicrobial Resistance with Metallo-β-lactamase Inhibitors.比金属还坚硬：用金属β-内酰胺酶抑制剂挑战抗菌药物耐药性
J Med Chem. 2025 Jun 12;68(11):10556-10576. doi: 10.1021/acs.jmedchem.5c00553. Epub 2025 May 30.
3
Elucidation of critical chemical moieties of metallo-β-lactamase inhibitors and prioritisation of target metallo-β-lactamases.
阐明金属β-内酰胺酶抑制剂的关键化学部分，并确定目标金属β-内酰胺酶的优先级。
J Enzyme Inhib Med Chem. 2024 Dec;39(1):2318830. doi: 10.1080/14756366.2024.2318830. Epub 2024 Mar 15.
4
Synthesis and biological evaluation of novel β-lactam-metallo β-lactamase inhibitors.新型β-内酰胺-金属β-内酰胺酶抑制剂的合成及生物学评价
RSC Adv. 2023 Jun 22;13(28):18991-19001. doi: 10.1039/d3ra02490c.
5
Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors.美罗培南与新型β-内酰胺-金属β-内酰胺酶抑制剂联合使用以中和碳青霉烯类耐药性
Antibiotics (Basel). 2023 Mar 23;12(4):633. doi: 10.3390/antibiotics12040633.
6
In Vitro and In Vivo Development of a β-Lactam-Metallo-β-Lactamase Inhibitor: Targeting Carbapenem-Resistant .β-内酰胺-金属β-内酰胺酶抑制剂的体外和体内研究：针对碳青霉烯类耐药菌。
ACS Infect Dis. 2023 Mar 10;9(3):486-496. doi: 10.1021/acsinfecdis.2c00485. Epub 2023 Feb 14.
7
Drug development concerning metallo-β-lactamases in gram-negative bacteria.针对革兰氏阴性菌中金属β-内酰胺酶的药物研发。
Front Microbiol. 2022 Sep 15;13:959107. doi: 10.3389/fmicb.2022.959107. eCollection 2022.
8
Enzyme Inhibitors: The Best Strategy to Tackle Superbug NDM-1 and Its Variants.酶抑制剂：应对超级细菌 NDM-1 及其变体的最佳策略。
Int J Mol Sci. 2021 Dec 24;23(1):197. doi: 10.3390/ijms23010197.
9
Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design.金属β-内酰胺酶在多药耐药时代：从结构和机制到进化、传播和抑制剂设计。
Chem Rev. 2021 Jul 14;121(13):7957-8094. doi: 10.1021/acs.chemrev.1c00138. Epub 2021 Jun 15.
10
Mechanistic Investigations of Metallo-β-lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition*.金属β-内酰胺酶抑制剂的作用机制研究：强烈的锌结合对于有效的酶抑制并非必需*。
ChemMedChem. 2021 May 18;16(10):1651-1659. doi: 10.1002/cmdc.202100042. Epub 2021 Mar 3.