Moodley Nareshni, Ngxamngxa Unathi, Turzyniecka Magdalena J, Pillay Tahir S
Department of Chemical Pathology & NHLS Inkosi Albert Luthuli Central Hospital, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Faculty of Health Sciences and Steve Biko Academic Hospital, Department of Chemical Pathology and NHLS Tshwane Academic Division, University of Pretoria, Pretoria, South Africa Division of Chemical Pathology, Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa.
J Clin Pathol. 2015 Apr;68(4):258-64. doi: 10.1136/jclinpath-2014-202672. Epub 2015 Jan 7.
This is the second in the series of historical articles dealing with developments in clinical pathology. As one of the most commonly measured analytes in pathology, the assessment of glucose dates back to the time of the ancient Egyptians. It was only in the 19th century that advances in chemistry led to the identification of the sugar in urine being glucose. The following century witnessed the development of more chemical and enzymatic methods which became incorporated into the modern analysers and point-of-care instruments which are as ubiquitous as the modern day cellphones. Tracking the milestones in these developments shows the striking paradigms and the many parallels in the development of other clinical chemistry methods.
这是关于临床病理学发展的系列历史文章中的第二篇。作为病理学中最常检测的分析物之一，葡萄糖的检测可追溯到古埃及时期。直到19世纪，化学的进步才使得尿液中的糖分被鉴定为葡萄糖。接下来的一个世纪见证了更多化学和酶法的发展，这些方法被纳入了现代分析仪和即时检测仪器中，如今它们就像现代手机一样无处不在。追踪这些发展中的里程碑，可以看到显著的范式以及其他临床化学方法发展中的许多相似之处。
