Santavirta Torsten, Santavirta Nina, Betancourt Theresa S, Gilman Stephen E
Swedish Institute for Social Research, Stockholm University, SE-10691, Stockholm, Sweden
Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland
BMJ. 2015 Jan 5;350:g7753. doi: 10.1136/bmj.g7753.
To compare the risks of admission to hospital for any type of psychiatric disorder and for four specific psychiatric disorders among adults who as children were evacuated to Swedish foster families during the second world war and their non-evacuated siblings, and to evaluate whether these risks differ between the sexes.
Cohort study.
National child evacuation scheme in Finland during the second world war.
Children born in Finland between 1933 and 1944 who were later included in a 10% sample of the 1950 Finnish census ascertained in 1997 (n = 45,463; women: n = 22,021; men: n = 23,442). Evacuees in the sample were identified from war time government records.
Adults admitted to hospital for psychiatric disorders recorded between 1971 and 2011 in the Finnish hospital discharge register.
We used Cox proportional hazards models to estimate the association between evacuation to temporary foster care in Sweden during the second world war and admission to hospital for a psychiatric disorder between ages 38 and 78 years. Fixed effects methods were employed to control for all unobserved social and genetic characteristics shared among siblings.
Among men and women combined, the risk of admission to hospital for a psychiatric disorder did not differ between Finnish adults evacuated to Swedish foster families and their non-evacuated siblings (hazard ratio 0.89, 95% confidence interval 0.64 to 1.26). Evidence suggested a lower risk of admission for any mental disorder (0.67, 0.44 to 1.03) among evacuated men, whereas for women there was no association between evacuation and the overall risk of admission for a psychiatric disorder (1.21, 0.80 to 1.83). When admissions for individual psychiatric disorders were analyzed, evacuated girls were significantly more likely than their non-evacuated sisters to be admitted to hospital for a mood disorder as an adult (2.19, 1.10 to 4.33).
The Finnish evacuation policy was not associated with an increased overall risk of admission to hospital for a psychiatric disorder in adulthood among former evacuees. In fact, evacuation was associated with a marginally reduced risk of admission for any psychiatric disorder among men. Among women who had been evacuated, however, the risk of being admitted to hospital for a mood disorder was increased.
比较在第二次世界大战期间作为儿童被疏散到瑞典寄养家庭的成年人及其未被疏散的兄弟姐妹中,因任何类型精神疾病以及四种特定精神疾病入院的风险,并评估这些风险在性别之间是否存在差异。
队列研究。
第二次世界大战期间芬兰的全国儿童疏散计划。
1933年至1944年在芬兰出生的儿童,他们后来被纳入1997年确定的1950年芬兰人口普查10%的样本中(n = 45463;女性:n = 22021;男性:n = 23442)。样本中的疏散人员从战时政府记录中识别出来。
1971年至2011年芬兰医院出院登记册中记录的因精神疾病入院的成年人。
我们使用Cox比例风险模型来估计第二次世界大战期间疏散到瑞典临时寄养家庭与38至78岁因精神疾病入院之间的关联。采用固定效应方法来控制兄弟姐妹之间共享的所有未观察到的社会和遗传特征。
在男性和女性中,疏散到瑞典寄养家庭的芬兰成年人与其未被疏散的兄弟姐妹因精神疾病入院的风险没有差异(风险比0.89,95%置信区间0.64至1.26)。有证据表明,疏散男性中因任何精神疾病入院的风险较低(0.67,0.44至1.03),而对于女性,疏散与因精神疾病入院的总体风险之间没有关联(1.21,0.80至1.83)。当分析个别精神疾病的入院情况时,疏散女孩成年后因情绪障碍入院的可能性明显高于未被疏散的姐妹(2.19,1.10至4.33)。
芬兰的疏散政策与前疏散人员成年后因精神疾病入院的总体风险增加无关。事实上,疏散与男性因任何精神疾病入院的风险略有降低有关。然而,在已被疏散的女性中,因情绪障碍入院的风险增加。