Ye Zhang-qun, Wang Tao, Song Wen
Department of Urology, Tongji Hospital, Huazhong University of Science and Technology, Hubei, China.
Zhonghua Nan Ke Xue. 2014 Nov;20(11):963-8.
Long non-coding RNAs (lncRNAs) are a group of RNA molecules which are longer than 200 nucleotides. They do not have functional open reading frames and cannot encode proteins. Recent studies have demonstrated that lncRNAs are widely involved in the regulation of gene expression network at epigenetic, transcriptional and post-transcriptional levels, which may affect the growth, proliferation, differentiation, metabolism, apoptosis and other important physiological processes of cells. The abnormal expression of lncRNAs is closely associated with the development, invasion, metastasis and prognosis of tumors. The development of prostate cancer is a multi-factor and multi-step process, in which abnormal gene expression may play an important role. This review focuses on the recent progress in the studies on the role of lncRNAs in prostate cancer, aiming for some new clues to the clinical prevention, diagnosis and treatment of this malignancy.
长链非编码RNA（lncRNAs）是一类长度超过200个核苷酸的RNA分子。它们没有功能性开放阅读框，不能编码蛋白质。最近的研究表明，lncRNAs广泛参与表观遗传、转录和转录后水平的基因表达网络调控，这可能影响细胞的生长、增殖、分化、代谢、凋亡及其他重要生理过程。lncRNAs的异常表达与肿瘤的发生、侵袭、转移及预后密切相关。前列腺癌的发生是一个多因素、多步骤的过程，其中基因异常表达可能起重要作用。本文综述了lncRNAs在前列腺癌中作用的研究进展，旨在为该恶性肿瘤的临床预防、诊断和治疗提供新线索。
