Doillon C J, Silver F H
Biomaterials. 1986 Jan;7(1):3-8. doi: 10.1016/0142-9612(86)90080-3.
Our previous studies have shown that a collagen-based wound dressing induces the spatial deposition of wound tissue. This study was conducted to determine the effects of hyaluronic acid and fibronectin on wound healing. These macromolecules play an important role in wound healing, embryonic development and cellular migration in vitro. The effects of the addition of varying levels of fibronectin and hyaluronate to a collagen sponge were studied. Low levels of both hyaluronate and fibronectin modified the structure of the implant, and resulted in increased chemoattraction, replication and collagen deposition in an in vivo wound healing model.
我们之前的研究表明，一种基于胶原蛋白的伤口敷料可诱导伤口组织的空间沉积。本研究旨在确定透明质酸和纤连蛋白对伤口愈合的影响。这些大分子在伤口愈合、胚胎发育和体外细胞迁移中起重要作用。研究了向胶原海绵中添加不同水平的纤连蛋白和透明质酸盐的效果。低水平的透明质酸盐和纤连蛋白均改变了植入物的结构，并在体内伤口愈合模型中导致趋化性、细胞增殖和胶原蛋白沉积增加。
