Natural antisense transcripts as therapeutic targets.
作者信息
Halley Paul, Khorkova Olga, Wahlestedt Claes
机构信息
Department of Psychiatry and Behavioral Sciences, and Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
OPKO-CURNA 10320 USA Today Way, Miramar, FL 33025, USA.
出版信息
Drug Discov Today Ther Strateg. 2013 Fall;10(3):e119-e125. doi: 10.1016/j.ddstr.2013.03.001.
Abstract
摘要
相似文献
1
Natural antisense transcripts as therapeutic targets.作为治疗靶点的天然反义转录本。
Drug Discov Today Ther Strateg. 2013 Fall;10(3):e119-e125. doi: 10.1016/j.ddstr.2013.03.001.
2
Natural Antisense Transcripts: Molecular Mechanisms and Implications in Breast Cancers.天然反义转录本：乳腺癌中的分子机制与意义。
Int J Mol Sci. 2018 Jan 2;19(1):123. doi: 10.3390/ijms19010123.
3
Natural antisense transcripts.天然反义转录本。
RNA Biol. 2005 Apr;2(2):53-62. doi: 10.4161/rna.2.2.1852. Epub 2005 Apr 19.
4
Natural antisense and noncoding RNA transcripts as potential drug targets.作为潜在药物靶点的天然反义RNA和非编码RNA转录本
Drug Discov Today. 2006 Jun;11(11-12):503-8. doi: 10.1016/j.drudis.2006.04.013.
5
Systematic search for natural antisense transcripts in eukaryotes (review).
Int J Mol Med. 2005 Feb;15(2):197-203.
6
Naturally occurring antisense RNA: function and mechanisms of action.天然反义RNA：功能及作用机制
Curr Opin Nephrol Hypertens. 2009 Jul;18(4):343-9. doi: 10.1097/MNH.0b013e32832cb982.
7
An experimental approach for systematic identification of antisense transcripts.一种用于系统鉴定反义转录本的实验方法。
Discov Med. 2004 Feb;4(20):58-60.
8
Natural antisense transcripts of the S locus receptor kinase gene and related sequences in Brassica oleracea.甘蓝中S位点受体激酶基因的天然反义转录本及相关序列
Mol Gen Genet. 1997 Aug;255(5):514-24. doi: 10.1007/s004380050524.
9
Natural Antisense Transcripts at the Interface between Host Genome and Mobile Genetic Elements.宿主基因组与可移动遗传元件界面处的天然反义转录本。
Front Microbiol. 2017 Nov 20;8:2292. doi: 10.3389/fmicb.2017.02292. eCollection 2017.
10
Differential expression profiles of sense and antisense transcripts between HCV-associated hepatocellular carcinoma and corresponding non-cancerous liver tissue.HCV 相关肝细胞癌与相应非癌性肝组织中正义和反义转录本的差异表达谱。
Int J Oncol. 2012 Jun;40(6):1813-20. doi: 10.3892/ijo.2012.1382. Epub 2012 Feb 21.
引用本文的文献
1
Biological and clinical relevance of correlated expression levels of coding and long noncoding RNAs in HPV16 positive cervical cancers.HPV16 阳性宫颈癌中编码 RNA 和长非编码 RNA 相关表达水平的生物学和临床意义。
Hum Genomics. 2024 Aug 29;18(1):91. doi: 10.1186/s40246-024-00660-2.
2
MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2.通过抑制 HPV16 相关宫颈癌启动子上的 H3K27me3 标记下调 MAL 表达与预后相关，并通过新型 MAL 反义长非编码 RNA AC103563.8、E7 癌蛋白和 EZH2 的相互作用表现出来。
Clin Epigenetics. 2024 Mar 10;16(1):40. doi: 10.1186/s13148-024-01651-9.
3
Non-coding RNAs in Precursor Lesions of Colorectal Cancer: Their Role in Cancer Initiation and Formation.非编码 RNA 在结直肠癌前病变中的作用：在癌症发生和形成中的作用。
Curr Mol Med. 2024;24(5):565-575. doi: 10.2174/1566524023666230523155719.
4
Antisense lncRNA is linked to glioma patient survival.反义长链非编码RNA与胶质瘤患者的生存率相关。
Front Mol Biosci. 2023 Mar 6;10:1101953. doi: 10.3389/fmolb.2023.1101953. eCollection 2023.
5
Circadian Oscillation of Natural Antisense Transcripts Related to Human Core Clock Genes.与人类核心生物钟基因相关的天然反义转录本的昼夜节律振荡
Rep Biochem Mol Biol. 2021 Oct;10(3):471-476. doi: 10.52547/rbmb.10.3.471.
6
Toward a New Paradigm for Targeted Natriuretic Peptide Enhancement in Heart Failure.迈向心力衰竭中利钠肽靶向增强的新范式。
Front Physiol. 2021 Oct 13;12:650124. doi: 10.3389/fphys.2021.650124. eCollection 2021.
7
lncRNA PCBP1-AS1 Aggravates the Progression of Hepatocellular Carcinoma via Regulating PCBP1/PRL-3/AKT Pathway.长链非编码RNA PCBP1-AS1通过调控PCBP1/PRL-3/AKT通路加重肝细胞癌进展。
Cancer Manag Res. 2020 Jul 6;12:5395-5408. doi: 10.2147/CMAR.S249657. eCollection 2020.
8
FAST-1 antisense RNA epigenetically alters FXN expression.FAST-1 反义 RNA 通过表观遗传修饰改变 FXN 的表达。
Sci Rep. 2018 Nov 21;8(1):17217. doi: 10.1038/s41598-018-35639-2.
9
The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2.长链非编码 RNA GATA6-AS 通过与 LOXL2 相互作用，表观遗传调控血管内皮基因表达。
Nat Commun. 2018 Jan 16;9(1):237. doi: 10.1038/s41467-017-02431-1.
10
OverGeneDB: a database of 5' end protein coding overlapping genes in human and mouse genomes.OverGeneDB：一个人类和鼠基因组中 5' 端蛋白编码重叠基因的数据库。
Nucleic Acids Res. 2018 Jan 4;46(D1):D186-D193. doi: 10.1093/nar/gkx948.
本文引用的文献
1
The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells.非编码 RNA MALAT1 是肺癌细胞转移表型的关键调节因子。
Cancer Res. 2013 Feb 1;73(3):1180-9. doi: 10.1158/0008-5472.CAN-12-2850. Epub 2012 Dec 14.
2
Annotation of functional variation in personal genomes using RegulomeDB.利用 RegulomeDB 注释个人基因组中的功能变异。
Genome Res. 2012 Sep;22(9):1790-7. doi: 10.1101/gr.137323.112.
3
An integrated encyclopedia of DNA elements in the human genome.人类基因组中 DNA 元件的综合百科全书。
Nature. 2012 Sep 6;489(7414):57-74. doi: 10.1038/nature11247.
4
The expression of tubulin cofactor A (TBCA) is regulated by a noncoding antisense Tbca RNA during testis maturation.微管相关蛋白 TBCA（Tubulin Cofactor A）的表达受到睾丸成熟过程中非编码反义 Tbca RNA 的调控。
PLoS One. 2012;7(8):e42536. doi: 10.1371/journal.pone.0042536. Epub 2012 Aug 6.
5
Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease.非编码 RNA 在大脑进化、发育、可塑性和疾病中的新兴作用。
Nat Rev Neurosci. 2012 Jul 20;13(8):528-41. doi: 10.1038/nrn3234.
6
Genome regulation by long noncoding RNAs.长非编码 RNA 的基因组调控。
Annu Rev Biochem. 2012;81:145-66. doi: 10.1146/annurev-biochem-051410-092902.
7
Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts.长非编码 RNA 调控染色质结构：聚焦天然反义转录本。
Trends Genet. 2012 Aug;28(8):389-96. doi: 10.1016/j.tig.2012.03.013. Epub 2012 Apr 26.
8
Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer.胃癌中 WDR83 与其天然反义转录本 DHPS 之间的双向调控。
Cell Res. 2012 Sep;22(9):1374-89. doi: 10.1038/cr.2012.57. Epub 2012 Apr 10.
9
Differential expression of long non-coding RNAs during genotoxic stress-induced apoptosis in HeLa and MCF-7 cells.在 HeLa 和 MCF-7 细胞中，遗传毒性应激诱导细胞凋亡过程中长链非编码 RNA 的差异表达。
Clin Exp Med. 2013 May;13(2):119-26. doi: 10.1007/s10238-012-0181-x. Epub 2012 Apr 10.
10
Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation.体内抑制天然反义转录本可导致基因特异性转录上调。
Nat Biotechnol. 2012 Mar 25;30(5):453-9. doi: 10.1038/nbt.2158.
Zotero 插件