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一例由弓蛔虫感染引起的疑似接触性皮炎病例。

A case of apparent contact dermatitis caused by Toxocara infection.

作者信息

Qualizza Rosanna, Makrì Eleni, Losappio Laura, Incorvaia Cristoforo

机构信息

Allergy Service, Istituti Clinici di Perfezionamento, 20100 Milan, Italy.

Allergy/Pulmonary Rehabilitation, Istituti Clinici di Perfezionamento, 20100 Milan, Italy.

出版信息

Case Rep Dermatol Med. 2014;2014:625724. doi: 10.1155/2014/625724. Epub 2014 Dec 16.

DOI:10.1155/2014/625724
PMID:25580310
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4280810/
Abstract

Infection from Toxocara species may give rise to a large array of clinical symptoms, including apparent manifestations of allergy such as asthma, urticaria/angioedema, and dermatitis. We report a case, thus far not described, of contact dermatitis attributed to nickel allergy but caused by Toxocara infection. The patient was a 53-year-old woman presenting from 10 years a dermatitis affecting head, neck, and thorax. Patch tests initially performed gave a positive result to nickel, but avoidance of contact with nickel did not result in recovery. The patient referred to our Allergy Service in 2010 because of dermatitis to feet. Patch testing confirmed the positive result for nickel, but expanding the investigation a positive result for IgG antibodies to Toxocara was detected by Western blotting and ELISA. Treatment with mebendazole achieved immediate efficacy on feet dermatitis. Then, two courses of treatment with albendazole resulted in complete regression of dermatitis accompanied by development of negative ELISA and Western blotting for Toxocara antibodies. This report adds another misleading presentation of Toxocara infection as apparent contact dermatitis caused by nickel and suggests bearing in mind, in cases of contact dermatitis not responding to avoidance of the responsible hapten and to medical treatment, the possible causative role of Toxocara.

摘要

弓蛔虫属感染可能引发一系列临床症状,包括哮喘、荨麻疹/血管性水肿和皮炎等明显的过敏表现。我们报告了一例迄今未被描述的接触性皮炎病例,该病例被认为是镍过敏所致,但实际由弓蛔虫感染引起。患者为一名53岁女性,10年来头部、颈部和胸部一直患有皮炎。最初进行的斑贴试验对镍呈阳性反应,但避免接触镍后病情并未好转。2010年,患者因足部皮炎转诊至我们的过敏科。斑贴试验再次证实对镍呈阳性反应,但进一步检查发现,通过蛋白质印迹法和酶联免疫吸附测定法检测到针对弓蛔虫的IgG抗体呈阳性。使用甲苯达唑治疗后,足部皮炎立即见效。随后,两疗程的阿苯达唑治疗使皮炎完全消退,同时酶联免疫吸附测定法和蛋白质印迹法检测弓蛔虫抗体呈阴性。本报告增加了弓蛔虫感染的另一种误导性表现,即看似由镍引起的接触性皮炎,并建议在接触性皮炎患者避免接触致敏半抗原和接受药物治疗均无效的情况下,考虑弓蛔虫可能的致病作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84d9/4280810/7d3f3a2c18ac/CRIDM2014-625724.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84d9/4280810/9dd5da4a40d4/CRIDM2014-625724.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84d9/4280810/7d3f3a2c18ac/CRIDM2014-625724.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84d9/4280810/9dd5da4a40d4/CRIDM2014-625724.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84d9/4280810/7d3f3a2c18ac/CRIDM2014-625724.002.jpg

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本文引用的文献

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Nickel allergy from adolescence to adulthood in the TOACS cohort.青少年至成年期的 TOACS 队列人群镍过敏情况。
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Int J Gen Med. 2011;4:783-7. doi: 10.2147/IJGM.S24324. Epub 2011 Nov 22.
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Toxocara canis infection: an important and neglected environmental risk factor for asthma?犬弓首蛔虫感染:哮喘一个重要却被忽视的环境风险因素?
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