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Lactobacillus rhamnosus GG and its SpaC pilus adhesin modulate inflammatory responsiveness and TLR-related gene expression in the fetal human gut.鼠李糖乳杆菌GG及其SpaC菌毛黏附素可调节人类胎儿肠道中的炎症反应和TLR相关基因表达。
Pediatr Res. 2015 Apr;77(4):528-35. doi: 10.1038/pr.2015.5. Epub 2015 Jan 12.
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Characterization of the SpaCBA pilus fibers in the probiotic Lactobacillus rhamnosus GG.鉴定益生菌鼠李糖乳杆菌 GG 中 SpaCBA 菌毛纤维的特性。
Appl Environ Microbiol. 2012 Apr;78(7):2337-44. doi: 10.1128/AEM.07047-11. Epub 2012 Jan 13.
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Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human- mucus binding protein.鼠李糖乳杆菌 GG 的比较基因组分析揭示了含有一种人-黏液结合蛋白的菌毛。
Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17193-8. doi: 10.1073/pnas.0908876106. Epub 2009 Sep 17.
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Epithelial adhesion mediated by pilin SpaC is required for Lactobacillus rhamnosus GG-induced cellular responses.鼠李糖乳杆菌GG诱导的细胞反应需要菌毛蛋白SpaC介导的上皮黏附。
Appl Environ Microbiol. 2014 Aug;80(16):5068-77. doi: 10.1128/AEM.01039-14. Epub 2014 Jun 13.
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Crystallization and X-ray Crystallographic Analysis of the Adhesive SpaC Pilin Subunit in the SpaCBA Pilus of Gut-adapted Lactobacillus rhamnosus GG.肠道适应性鼠李糖乳杆菌GG的SpaCBA菌毛中黏附性SpaC菌毛亚基的结晶及X射线晶体学分析
Protein Pept Lett. 2016;23(4):365-71. doi: 10.2174/0929866523666160106153055.
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Functional analysis of Lactobacillus rhamnosus GG pili in relation to adhesion and immunomodulatory interactions with intestinal epithelial cells.鼠李糖乳杆菌 GG 菌毛功能分析与其与肠道上皮细胞黏附和免疫调节相互作用的关系。
Appl Environ Microbiol. 2012 Jan;78(1):185-93. doi: 10.1128/AEM.06192-11. Epub 2011 Oct 21.
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Lactobacillus rhamnosus GG components, SLP, gDNA and CpG, exert protective effects on mouse macrophages upon lipopolysaccharide challenge.鼠李糖乳杆菌 GG 成分、SLP、gDNA 和 CpG，在脂多糖刺激时对小鼠巨噬细胞发挥保护作用。
Lett Appl Microbiol. 2020 Feb;70(2):118-127. doi: 10.1111/lam.13255. Epub 2019 Dec 18.
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Immunomodulation and signaling mechanism of Lactobacillus rhamnosus GG and its components on porcine intestinal epithelial cells stimulated by lipopolysaccharide.鼠李糖乳杆菌 GG 及其成分对脂多糖刺激的猪肠上皮细胞的免疫调节及信号转导机制。
J Microbiol Immunol Infect. 2017 Oct;50(5):700-713. doi: 10.1016/j.jmii.2015.05.002. Epub 2015 May 14.
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Lactobacillus rhamnosus GG SpaC pilin subunit binds to the carbohydrate moieties of intestinal glycoconjugates.鼠李糖乳杆菌GG SpaC菌毛亚基与肠道糖缀合物的碳水化合物部分结合。
Anim Sci J. 2016 Jun;87(6):809-15. doi: 10.1111/asj.12491. Epub 2015 Oct 5.
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Crystal structure of lactobacillar SpaC reveals an atypical five-domain pilus tip adhesin: Exposing its substrate-binding and assembly in SpaCBA pili.乳杆菌 SpaC 的晶体结构揭示了一种非典型的五结构域菌毛尖端黏附素：揭示其在 SpaCBA 菌毛中的底物结合和组装。
J Struct Biol. 2020 Sep 1;211(3):107571. doi: 10.1016/j.jsb.2020.107571. Epub 2020 Jul 10.
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The Beneficial Effects of Lactobacillus Strains on Gut Microbiome in Alzheimer's Disease: A Systematic Review.乳酸杆菌菌株对阿尔茨海默病肠道微生物群的有益作用：一项系统综述
Healthcare (Basel). 2025 Jan 3;13(1):74. doi: 10.3390/healthcare13010074.
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Effect of Lactic Acid Bacteria-Derived Postbiotic Supplementation on Tuberculosis in Wild Boar Populations.乳酸菌来源的后生元补充剂对野猪种群结核病的影响。
Pathogens. 2024 Dec 8;13(12):1078. doi: 10.3390/pathogens13121078.
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Development of a therapeutic delivery platform with reduced colonization potential.开发一种具有降低定植潜力的治疗性药物输送平台。
Appl Environ Microbiol. 2024 Nov 20;90(11):e0031224. doi: 10.1128/aem.00312-24. Epub 2024 Oct 31.
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Probiotics in the Management of Vulvovaginal Candidosis.益生菌在念珠菌性外阴阴道炎治疗中的应用
J Clin Med. 2024 Aug 30;13(17):5163. doi: 10.3390/jcm13175163.
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GG triggers intestinal epithelium injury in zebrafish revealing host dependent beneficial effects.GG在斑马鱼中引发肠道上皮损伤，揭示了宿主依赖性有益效应。
Imeta. 2024 Mar 25;3(2):e181. doi: 10.1002/imt2.181. eCollection 2024 Apr.
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Prevention and treatment of antibiotics-associated adverse effects through the use of probiotics: A review.通过使用益生菌预防和治疗抗生素相关不良反应：综述
J Adv Res. 2025 May;71:209-226. doi: 10.1016/j.jare.2024.06.006. Epub 2024 Jun 4.
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The Therapeutic Effects of Probiotic on Systemic Lupus Erythematosus in Lupus Mice Models: A Systematic Review.益生菌对狼疮小鼠模型系统性红斑狼疮的治疗作用：一项系统评价
Probiotics Antimicrob Proteins. 2025 Feb;17(1):35-50. doi: 10.1007/s12602-024-10297-1. Epub 2024 May 28.
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Therapeutic Potential of Gut Microbiota and Its Metabolite Short-Chain Fatty Acids in Neonatal Necrotizing Enterocolitis.肠道微生物群及其代谢产物短链脂肪酸在新生儿坏死性小肠结肠炎中的治疗潜力
Life (Basel). 2023 Feb 16;13(2):561. doi: 10.3390/life13020561.
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The Potential Therapeutic Role of for Treatment of Inflammatory Bowel Disease.用于治疗炎症性肠病的潜在治疗作用。
你提供的原文似乎不完整，“The Potential Therapeutic Role of for Treatment of Inflammatory Bowel Disease.” 这里中间少了具体的某个东西。
Foods. 2023 Feb 5;12(4):692. doi: 10.3390/foods12040692.
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Effect of the Microbiome on Intestinal Innate Immune Development in Early Life and the Potential Strategy of Early Intervention.肠道微生物群对生命早期肠道固有免疫发育的影响及早期干预的潜在策略。
Front Immunol. 2022 Jul 19;13:936300. doi: 10.3389/fimmu.2022.936300. eCollection 2022.
本文引用的文献
1
Do pregnancy-related changes in the microbiome stimulate innate immunity?孕期微生物组变化是否会刺激固有免疫？
Trends Mol Med. 2013 Aug;19(8):454-9. doi: 10.1016/j.molmed.2013.06.002. Epub 2013 Jul 8.
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Using recombinant Lactococci as an approach to dissect the immunomodulating capacity of surface piliation in probiotic Lactobacillus rhamnosus GG.利用重组乳球菌作为一种方法来剖析益生菌鼠李糖乳杆菌 GG 表面菌毛的免疫调节能力。
PLoS One. 2013 May 14;8(5):e64416. doi: 10.1371/journal.pone.0064416. Print 2013.
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Adhesion and nanomechanics of pili from the probiotic Lactobacillus rhamnosus GG.从益生菌鼠李糖乳杆菌 GG 中提取菌毛的黏附性和纳米力学。
ACS Nano. 2013 Apr 23;7(4):3685-97. doi: 10.1021/nn400705u. Epub 2013 Mar 26.
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Probiotics prevent necrotizing enterocolitis by modulating enterocyte genes that regulate innate immune-mediated inflammation.益生菌通过调节调节固有免疫介导的炎症的肠细胞基因来预防坏死性小肠结肠炎。
Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15;304(2):G132-41. doi: 10.1152/ajpgi.00142.2012. Epub 2012 Nov 8.
5
Probiotics in the development and treatment of allergic disease.益生菌在过敏性疾病的发生和治疗中的作用。
Gastroenterol Clin North Am. 2012 Dec;41(4):747-62. doi: 10.1016/j.gtc.2012.08.007.
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Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant.母亲在孕期和哺乳期补充益生菌可降低婴儿患湿疹的风险。
J Allergy Clin Immunol. 2012 Dec;130(6):1355-60. doi: 10.1016/j.jaci.2012.09.003. Epub 2012 Oct 16.
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Human intestinal dendritic cells decrease cytokine release against Salmonella infection in the presence of Lactobacillus paracasei upon TLR activation.TLR 激活时，人肠道树突状细胞在副干酪乳杆菌存在下对抗沙门氏菌感染时细胞因子释放减少。
PLoS One. 2012;7(8):e43197. doi: 10.1371/journal.pone.0043197. Epub 2012 Aug 14.
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Microbial contact during pregnancy, intestinal colonization and human disease.孕期微生物接触、肠道定植与人类疾病
Nat Rev Gastroenterol Hepatol. 2012 Oct;9(10):565-76. doi: 10.1038/nrgastro.2012.144. Epub 2012 Aug 14.
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Host remodeling of the gut microbiome and metabolic changes during pregnancy.宿主对肠道微生物组的重塑及妊娠期间的代谢变化。
Cell. 2012 Aug 3;150(3):470-80. doi: 10.1016/j.cell.2012.07.008.
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Probiotics modulate host-microbe interaction in the placenta and fetal gut: a randomized, double-blind, placebo-controlled trial.益生菌调节胎盘和胎儿肠道中的宿主-微生物相互作用：一项随机、双盲、安慰剂对照试验。
Neonatology. 2012;102(3):178-84. doi: 10.1159/000339182. Epub 2012 Jul 6.
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