环磷酰胺诱导晚期结节性多动脉炎缓解。

Cyclophosphamide-induced remissions in advanced polyarteritis nodosa.

作者信息

Fauci A S, Doppman J L, Wolff S M

出版信息

Am J Med. 1978 May;64(5):890-4. doi: 10.1016/0002-9343(78)90533-8.

Abstract

Two patients with far advanced polyarteritis nodosa involving multiple organ systems and with aneurysm formation demonstrable by celiac axis and renal arteriograms were treated with oral cyclophosphamide, 1 to 2 mg/kg/day, and alternate day prednisone therapy. Dramatic remissions of disease activity were achieved within weeks of initiation of therapy. Repeat angiograms obtained after one year revealed complete resolution of all aneurysms. Both patients are now receiving only cyclophosphamide and are maintained in complete remission 27 and 18 months after the start of therapy. Cyclophosphamide therapy can thus be highly effective even in far advanced polyarteritis nodosa.

摘要

两名患有累及多器官系统的晚期结节性多动脉炎且通过腹腔动脉造影和肾动脉造影可显示有动脉瘤形成的患者，接受了口服环磷酰胺治疗，剂量为每日1至2毫克/千克，并隔天给予泼尼松治疗。治疗开始数周内疾病活动即显著缓解。一年后复查血管造影显示所有动脉瘤完全消退。两名患者目前仅接受环磷酰胺治疗，自治疗开始后27个月和18个月一直保持完全缓解。因此，即使是晚期结节性多动脉炎，环磷酰胺治疗也可能非常有效。