Nerurkar V R, Chitale A R, Jalnapurkar B V, Naik S N, Lalitha V S
Cancer Research Institute, Bombay, India.
J Comp Pathol. 1989 Nov;101(4):389-97. doi: 10.1016/0021-9975(89)90022-4.
The pathological features of 52 canine mammary tumours were studied and compared with those of human breast neoplasms. In many of the former, the constituent cells were both epithelial and myoepithelial. Cartilaginous and osseous metaplasia of the stromal tissue was striking in a few tumours. Carcinosarcomas were also encountered. On a careful search, virus-like particles were observed in five tumours. The similarities and differences between the human and canine mammary tumours were discussed with a view to assessing the suitability of dog mammary tumour as an animal model for human breast tumours.
对52例犬乳腺肿瘤的病理特征进行了研究，并与人类乳腺肿瘤的病理特征进行了比较。在许多犬乳腺肿瘤中，组成细胞既有上皮细胞又有肌上皮细胞。少数肿瘤的间质组织出现软骨化生和骨化生，十分显著。还发现了癌肉瘤。经仔细检查，在5个肿瘤中观察到病毒样颗粒。讨论了人类和犬类乳腺肿瘤之间的异同，以评估犬乳腺肿瘤作为人类乳腺肿瘤动物模型的适用性。
