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核苷类似物对人类免疫缺陷病毒的体外骨髓毒性

In vitro bone marrow toxicity of nucleoside analogs against human immunodeficiency virus.

作者信息

Inoue T, Tsushita K, Itoh T, Ogura M, Hotta T, Saneyoshi M, Yoshida S, Saitoh H, Tomoda Y, Nagai Y

机构信息

Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan.

出版信息

Antimicrob Agents Chemother. 1989 Apr;33(4):576-9. doi: 10.1128/AAC.33.4.576.

DOI:10.1128/AAC.33.4.576
PMID:2543285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC172483/
Abstract

3'-Azido-2',3'-dideoxythymidine is known to cause severe anemia and neutropenia. Although these are rare for 2',3'-dideoxycytidine, it frequently impairs thrombocytogenesis. These differential myelossuppressive features correlated well with the in vitro toxicities of the drugs for a megakaryoblastic cell line and for colony formation of erythroid and granulocytic cells.

摘要

已知3'-叠氮-2',3'-双脱氧胸苷会导致严重贫血和中性粒细胞减少。虽然这些情况在2',3'-双脱氧胞苷中较为罕见，但它经常损害血小板生成。这些不同的骨髓抑制特征与药物对巨核母细胞系以及红系和粒系细胞集落形成的体外毒性密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d53/172483/3cf45a03a983/aac00072-0190-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d53/172483/3cf45a03a983/aac00072-0190-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d53/172483/3cf45a03a983/aac00072-0190-a.jpg

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本文引用的文献

1
Effects of 2',3'-dideoxynucleosides on mammalian cells and viruses.2',3'-二脱氧核苷对哺乳动物细胞和病毒的影响。
J Cell Physiol. 1984 Nov;121(2):402-8. doi: 10.1002/jcp.1041210218.
2
Erythroid colony formation in cultures of mouse and human bone marrow: analysis of the requirement for erythropoietin by gel filtration and affinity chromatography on agarose-concanavalin A.小鼠和人骨髓培养中的红系集落形成：通过琼脂糖-伴刀豆球蛋白A凝胶过滤和亲和层析分析对促红细胞生成素的需求
J Cell Physiol. 1974 Apr;83(2):309-20. doi: 10.1002/jcp.1040830218.
3
The growth of mouse bone marrow cells in vitro.
用于评估非致癌性血液毒性的替代测试系统。
Environ Health Perspect. 1998 Apr;106 Suppl 2(Suppl 2):541-57. doi: 10.1289/ehp.98106541.
4
Stavudine: a review of its pharmacodynamic and pharmacokinetic properties and clinical potential in HIV infection.
Drugs. 1996 May;51(5):846-64. doi: 10.2165/00003495-199651050-00009.
5
3'-azido-3'-deoxythymidine (AZT) monophosphate: an inhibitor of exonucleolytic repair of AZT-terminated DNA.3'-叠氮-3'-脱氧胸苷单磷酸（AZT）：一种AZT末端DNA外切核酸酶修复的抑制剂。
Antimicrob Agents Chemother. 1993 Apr;37(4):918-20. doi: 10.1128/AAC.37.4.918.
6
The toxicity of azidothymidine (AZT) on human and animal cells in culture at concentrations used for antiviral therapy.
Genetica. 1995;95(1-3):103-9. doi: 10.1007/BF01435004.
7
Antiviral therapy in human immunodeficiency virus infections. Current status (Part II).人类免疫缺陷病毒感染中的抗病毒治疗。现状（第二部分）
Drugs. 1993 May;45(5):637-53. doi: 10.2165/00003495-199345050-00002.
8
In vitro and in vivo evidence that the antiviral activity of 2',3'-dideoxycytidine is target cell dependent in a feline retrovirus animal model.在猫逆转录病毒动物模型中，2',3'-二脱氧胞苷的抗病毒活性依赖于靶细胞的体外和体内证据。
Antimicrob Agents Chemother. 1990 Jul;34(7):1414-21. doi: 10.1128/AAC.34.7.1414.
9
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Antimicrob Agents Chemother. 1991 Feb;35(2):322-8. doi: 10.1128/AAC.35.2.322.
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4
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.作为潜在抗HIV（HTLV-III/LAV）药物的3'-取代的2',3'-二脱氧核苷类似物。
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5
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Antimicrob Agents Chemother. 1987 Mar;31(3):452-4. doi: 10.1128/AAC.31.3.452.
6
The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.齐多夫定（AZT）治疗艾滋病及艾滋病相关综合征患者的毒性。一项双盲、安慰剂对照试验。
N Engl J Med. 1987 Jul 23;317(4):192-7. doi: 10.1056/NEJM198707233170402.
7
Potential anti-AIDS drugs. 2',3'-Dideoxycytidine analogues.潜在的抗艾滋病药物。2'，3'-双脱氧胞苷类似物。
J Med Chem. 1987 May;30(5):862-6. doi: 10.1021/jm00388a020.
8
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Biochem Pharmacol. 1986 Jul 1;35(13):2065-8. doi: 10.1016/0006-2952(86)90571-x.
9
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Proc Natl Acad Sci U S A. 1986 Mar;83(6):1911-5. doi: 10.1073/pnas.83.6.1911.
10
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Blood. 1985 Dec;66(6):1384-92.